@article {1689, title = {A 3{\textquoteright}UTR SNP in NLRP3 gene is associated with susceptibility to HIV-1 infection.}, journal = {J Acquir Immune Defic Syndr}, volume = {54}, year = {2010}, month = {2010 Jul}, pages = {236-40}, abstract = {

OBJECTIVES: Innate immunity genes polymorphisms are known to be involved in the multifactorial susceptibility to HIV-1 infection. Recently it has been hypothesized that inflammasomes could play an important role in the host response to viruses. The aim of our study is to verify if single-nucleotide polymorphisms (SNPs) in genes encoding for NALPs-innate immune receptors that form molecular complexes leading to the production of IL-1beta and the activation of immune response-could influence the individual susceptibility to HIV-1.

DESIGN: We performed an association study analyzing 2 NLRP1 and NLRP3 SNPs in HIV-1 vertically infected Brazilian children (n = 135), HIV-1-infected Brazilain adults (n = 192) and HIV-1-positive Italian seropositive subjects (n = 192).

RESULTS: The 3{\textquoteright}UTR NLRP3 rs10754558 SNP was associated with HIV-1 infection in all the studied groups. The frequency of rs10754558 G allele was differently distributed within seropositive subjects (HIV+) and controls, and in particular the GG genotype was less frequent in HIV+.

CONCLUSIONS: susceptibility to HIV-1 infection is associated with a 3{\textquoteright}UTR NLRP3 polymorphism. This is the first report linking SNPs in the NALPs with HIV-1 infection, and further epidemiologic and functional studies are needed to deeper investigate the role of inflammasome in the susceptibility to HIV-1 infection.

}, keywords = {Adult, Brazil, Carrier Proteins, Case-Control Studies, Child, Child, Preschool, Female, Genetic Predisposition to Disease, Genotype, HIV Infections, HIV-1, Humans, Infant, Infectious Disease Transmission, Vertical, Male, Middle Aged, Polymorphism, Single Nucleotide, Pregnancy, Young Adult}, issn = {1944-7884}, doi = {10.1097/QAI.0b013e3181dd17d4}, author = {Pontillo, Alessandra and Brand{\~a}o, Lucas A and Guimar{\~a}es, Rafael L and Segat, Ludovica and Athanasakis, Emmanouil and Crovella, Sergio} }