@article {8291, title = {Association of the HLA-G 3{\textquoteright}UTR polymorphisms with colorectal cancer in Italy: a first insight.}, journal = {Int J Immunogenet}, volume = {43}, year = {2016}, month = {2016 Feb}, pages = {32-9}, abstract = {

This study aimed to explore functional and regulatory polymorphisms and haplotypes at the HLA-G 3{\textquoteright}UTR region in colorectal cancer development. The presence of nonpolymorphic variants was also evaluated. Three-hundred and eight patients with colorectal cancer and 294 healthy controls were analysed at the germinal level. We found an association with increased risk of colorectal cancer for +2960 14-bp INDEL, +3196 C>G SNPs and UTR-2 haplotype, and a {\textquoteright}protective{\textquoteright} role for +3003 T>C, +3010 C>G polymorphisms and UTR-4 haplotype. We detected in 3 distinct patients, a novel nucleotide change (+3037 C>A) and 2 already described rare variants, +3032 G/C (EUR MAF~=~0.1\%) and +3092~G/T (EUR MAF~=~0\%). This is the first study showing associations between different polymorphisms in the HLA-G 3{\textquoteright}UTR and colorectal cancer susceptibility.

}, issn = {1744-313X}, doi = {10.1111/iji.12243}, author = {Garziera, M and Catamo, E and Crovella, S and Montico, M and Cecchin, E and Lonardi, S and Mini, E and Nobili, S and Romanato, L and Toffoli, G} }