TY - JOUR T1 - Thrombogenesis in Thrombophilic Pregnancy: Evaluation of Low-Molecular-Weight Heparin Prophylaxis. JF - Acta Haematol Y1 - 2017 A1 - Simeone, Roberto A1 - Giacomello, Roberta A1 - Bruno, Germano A1 - Parco, Sergio A1 - Maximova, Natalia A1 - Martinelli, Monica A1 - Zito, Gabriella A1 - Luppi, Stefania A1 - Cervi, Gina A1 - Ricci, Giuseppe KW - Adult KW - Anticoagulants KW - Case-Control Studies KW - Factor Xa Inhibitors KW - Female KW - Heparin, Low-Molecular-Weight KW - Humans KW - Nadroparin KW - Partial Thromboplastin Time KW - Peptide Fragments KW - Pilot Projects KW - Pregnancy KW - Pregnancy Complications, Hematologic KW - Prothrombin KW - Thrombophilia KW - Thrombosis AB -

The aim of this study is to investigate thrombogenesis and the hypercoagulable changes in pregnant women affected by thrombophilia who received low-molecular-weight heparin (LWMH) prophylaxis. We included 21 pregnant women affected by thrombophilia treated with LWMH and 20 nontreated normal pregnant women as the control group. The sample group of thrombophilic pregnant women included different conditions (factor V Leiden mutation, protein C deficiency, protein S deficiency, antiphospholipid antibodies syndrome, and combined defects). Three blood samples were collected during pregnancy (i.e., at 16, 20, and 24 weeks) and tested for activated partial thromboplastin time and prothrombin fragment F1 + 2 (F1 + 2); anti-FXa activity was tested only in treated thrombophilic pregnant women. F1 + 2 levels progressively increased during pregnancy in both study groups. However, the F1 + 2 increase in women exposed to heparin prophylaxis was significantly lower than that in normal pregnant women in all 3 measurements carried out during gestation (p < 0.05); a statistically significant inverse correlation between F1 + 2 levels and anti-Xa activity (R = -0.8575, p < 0.05) was observed in treated women during pregnancy. Our findings suggest that F1 + 2 in addition to anti-Xa measurement could be used to adjust LWMH prophylaxis, at least in high-risk pregnant women.

VL - 137 IS - 4 U1 - http://www.ncbi.nlm.nih.gov/pubmed/28478442?dopt=Abstract ER -