TY - JOUR T1 - Acute lobar nephritis in children: Not so easy to recognize and manage. JF - World J Clin Pediatr Y1 - 2016 A1 - Bibalo, Cristina A1 - Apicella, Andrea A1 - Guastalla, Veronica A1 - Marzuillo, Pierluigi A1 - Zennaro, Floriana A1 - Tringali, Carmela A1 - Taddio, Andrea A1 - Germani, Claudio A1 - Barbi, Egidio AB -

Acute lobar nephritis (ALN) is a localized non-liquefactive inflammatory renal bacterial infection, which typically involves one or more lobes. ALN is considered to be a midpoint in the spectrum of upper urinary tract infection, a spectrum ranging from uncomplicated pyelonephritis to intrarenal abscess. This condition may be difficult to recognize due to the lack of specific symptoms and laboratory findings. Therefore the disease is probably underdiagnosed. Computed tomography scanning represents the diagnostic gold standard for ALN, but magnetic resonance imagine could be considered in order to limit irradiation. The diagnosis is relevant since initial intravenous antibiotic therapy and overall length of treatment should not be shorter than 3 wk. We review the literature and analyze the ALN clinical presentation starting from four cases with the aim to give to the clinicians the elements to suspect and recognize the ALN in children.

VL - 5 IS - 1 U1 - http://www.ncbi.nlm.nih.gov/pubmed/26862513?dopt=Abstract ER - TY - JOUR T1 - Decline in Lung Function in Childhood Asthma. JF - N Engl J Med Y1 - 2016 A1 - Bibalo, Cristina A1 - Longo, Giorgio A1 - Ventura, Alessandro KW - Anti-Inflammatory Agents KW - Asthma KW - Female KW - Humans KW - Lung KW - Male VL - 375 IS - 7 U1 - http://www.ncbi.nlm.nih.gov/pubmed/27532854?dopt=Abstract ER - TY - JOUR T1 - Relapse and metastasis of atypical teratoid/rhabdoid tumor in a boy with neurofibromatosis type 1 treated with recombinant human growth hormone. JF - Neuropediatrics Y1 - 2015 A1 - Tornese, Gianluca A1 - Faleschini, Elena A1 - Matarazzo, Lorenza A1 - Bibalo, Cristina A1 - Zanazzo, Giulio Andrea A1 - Rabusin, Marco A1 - Tonini, Giorgio A1 - Zennaro, Floriana A1 - Ventura, Alessandro KW - Brain Stem Neoplasms KW - Cerebellar Neoplasms KW - Child KW - Human Growth Hormone KW - Humans KW - Magnetic Resonance Imaging KW - Male KW - Neurofibromatosis 1 KW - Recombinant Proteins KW - Recurrence KW - Rhabdoid Tumor KW - Risk Factors KW - Teratoma AB -

Even though no increased recurrence rate seems to be reported in patients with brain tumors receiving recombinant human growth hormone (rhGH) replacement, in some patients multiple risk factors could put at higher risk for recurrence. In such cases, the decision to start rhGH therapy should be very cautious. A boy with neurofibromatosis type 1 developed an atypical teratoid/rhabdoid tumor (AT/RT) of right cerebellum, treated with surgery, radiotherapy, and chemotherapy. After 3 years of remission, he started rhGH for growth hormone deficiency, having a negative magnetic resonance imaging (MRI) scan. Ten weeks after starting therapy, the boy became symptomatic and MRI showed relapse of AT/RT in the right cerebellum and a new lesion in the brainstem. The boy died of progressive disease. In this case, the connection between AT/RT recurrence and the beginning of rhGH therapy, with a negative pretreatment MRI, cannot be excluded. Additional caution should be used for rhGH in patients with multiple risk factors.

VL - 46 IS - 2 U1 - http://www.ncbi.nlm.nih.gov/pubmed/25625887?dopt=Abstract ER - TY - JOUR T1 - Treatment of asthma based on symptoms. JF - J Pediatr Y1 - 2015 A1 - Bibalo, Cristina A1 - Longo, Giorgio A1 - Ventura, Alessandro KW - Asthma KW - Female KW - Humans KW - Male KW - Spirometry VL - 166 IS - 5 U1 - http://www.ncbi.nlm.nih.gov/pubmed/25771387?dopt=Abstract ER -