@article {1658, title = {A multicenter, case-control study on risk factors for antepartum stillbirth.}, journal = {J Matern Fetal Neonatal Med}, volume = {24}, year = {2011}, month = {2011 Mar}, pages = {407-10}, abstract = {

OBJECTIVE: As the influence of socio-demographic variables, lifestyle and medical conditions on the epidemiology of stillbirth (SB) is modified by population features, we aimed at investigating the role played by these factors on the incidence of SB in a developed country.

STUDY DESIGN: Multivariate logistic regression analysis (OR with 95\% CI) was utilized in a prospective multicentre nested case-control study to compare in a 1:2 ratio stillborn of >22 weeks gestation with matched for gestational age live-born (LB) infants. Intrapartum SB were excluded.

RESULTS: Two hundred fifty-four consecutive SBs and 497 LBs were enrolled. Socio-demographic variables were equally distributed. Fetal malformations (7.96, 2.69-23.55), severe intrauterine growth restriction (IUGR) (birthweight <= 5(th) \%ile) (4.32, 2.27?8.24), BMI > 25 (2.87, 1.90-4.33), and preeclampsia (PE, 0.40, 0.21-0.77) were recognized as independent predictors for SB. At term, only BMI > 25 was associated with SB (7.70, 2.9-20.5).

CONCLUSION: Fetal malformations, severe IUGR and maternal BMI > 25 were associated with a significant increase in the risk of SB; PE presented instead a protective role. Maternal BMI > 25 was the only risk factor for SB identified in term pregnancies.

}, keywords = {Adult, Case-Control Studies, Cause of Death, Congenital Abnormalities, Female, Fetal Death, Fetal Growth Retardation, Humans, Infant, Newborn, Male, Obstetric Labor Complications, Pre-Eclampsia, Pregnancy, Risk Factors, Stillbirth, Young Adult}, issn = {1476-4954}, doi = {10.3109/14767058.2010.496880}, author = {Facchinetti, Fabio and Alberico, Salvatore and Benedetto, Chiara and Cetin, Irene and Cozzolino, Sabrina and Di Renzo, Gian Carlo and Del Giovane, Cinzia and Ferrari, Francesca and Mecacci, Federico and Menato, Guido and Tranquilli, Andrea L and Baronciani, Dante} }