@article {1699,
	title = {Mesenchymal stem cells display hepato-protective activity in lymphoma bearing xenografts.},
	journal = {Invest New Drugs},
	volume = {30},
	year = {2012},
	month = {2012 Apr},
	pages = {803-7},
	abstract = {<p>A disseminated model of non-Hodgkin{\textquoteright}s lymphoma with prevalent liver metastasis was generated by intraperitoneal (i.p.) injection of EBV(+) B lymphoblastoid SKW6.4 in nude-SCID mice. The survival of SKW6.4 xenografts (median survival = 27 days) was significantly improved when hyaluronan scaffolds embedded with mesenchimal stem cells (MSC) were implanted in the abdominal area 4 days after SKW6.4 injection (median survival = 39.5 days). Mice implanted with MSC showed a significant improvement of hepatic functionality in lymphoma xenografts, as demonstrated by measurement of serum ALT/AST levels. Co-culture of MSC with lymphoma cells enhanced the release of hepatocyte growth factor (HGF) by MSC. These data suggest that hyaluronan-embedded MSC exert anti-lymphoma activity by ameliorating hepatic functionality.</p>},
	keywords = {Alanine Transaminase, Animals, Aspartate Aminotransferases, Biological Markers, Cell Communication, Cell Line, Tumor, Cell Survival, Coculture Techniques, Hepatocyte Growth Factor, Humans, Hyaluronic Acid, Liver, Liver Neoplasms, Lymphoma, Non-Hodgkin, Mesenchymal Stem Cell Transplantation, Mesenchymal Stromal Cells, Mice, Mice, Nude, Mice, SCID, Time Factors, Tissue Scaffolds, Xenograft Model Antitumor Assays},
	issn = {1573-0646},
	doi = {10.1007/s10637-010-9534-z},
	author = {Secchiero, Paola and Corallini, Federica and Zavan, Barbara and Tripodo, Claudio and Vindigni, Vincenzo and Zauli, Giorgio}
}
