@article {1752,
	title = {A polymorphism in PRF1 gene is associated with HIV-1 vertical transmission in Brazilian children.},
	journal = {AIDS},
	volume = {25},
	year = {2011},
	month = {2011 Feb 20},
	pages = {535-7},
	abstract = {<p>We investigated the possible association between PRF1 gene polymorphisms and HIV-1 vertical transmission in Brazilian children by analyzing PRF1 gene coding and untranslated regions in 173 perinatally infected children (HIV+), 51 exposed uninfected (HIV-), and 171 HIV-unexposed uninfected children. Seven single nucleotide polymorphisms were identified in our samples. The rs885822 C allele and CC genotype were significantly more frequent in HIV-negative than in HIV-positive patients and associated with a protective effect toward HIV vertical transmission.</p>},
	keywords = {Brazil, Female, HIV Infections, HIV-1, Humans, Infant, Newborn, Infectious Disease Transmission, Vertical, Male, Polymorphism, Genetic, Pore Forming Cytotoxic Proteins, Pregnancy},
	issn = {1473-5571},
	doi = {10.1097/QAD.0b013e3283428b7c},
	author = {Padovan, Lara and Segat, Ludovica and Crovella, Sergio}
}
