@article {1866,
	title = {The MDM2 inhibitor Nutlin-3 modulates dendritic cell-induced T cell proliferation.},
	journal = {Hum Immunol},
	volume = {73},
	year = {2012},
	month = {2012 Apr},
	pages = {342-5},
	abstract = {<p>Nutlin-3, a small molecule inhibitor of the MDM2/p53 interaction, has been recently taken into consideration as a promising therapeutic tool for tumor treatment based on its ability to stabilize and activate the p53 transcription factor pathway. Since Nutlin-3 displays non cell-autonomous tumor-suppressor activities, we wanted to investigate its effect on dendritic cell functions, given the central role of these cells in the modulation of the immune response. We found that Nutlin-3 alone slightly affected the levels of major histocompatibility complex and costimulatory molecules and significantly promoted the ability of dendritic cells to stimulate T cells in the mixed lymphocyte reaction. Taken together, our findings suggest that the ability of Nutlin-3 to modulate dendritic cell functions and therefore lymphocyte proliferation might represent an additional important mechanism by which Nutlin-3 exerts its non cell-autonomous tumor-suppression function.</p>},
	keywords = {Dendritic Cells, Humans, Imidazoles, Immunologic Factors, Immunophenotyping, Lymphocyte Activation, Piperazines, Proto-Oncogene Proteins c-mdm2, T-Lymphocytes},
	issn = {1879-1166},
	doi = {10.1016/j.humimm.2012.01.018},
	author = {Gasparini, Chiara and Tommasini, Alberto and Zauli, Giorgio}
}
