@article {1905,
	title = {Polymorphisms in inflammasome{\textquoteright} genes and susceptibility to HIV-1 infection.},
	journal = {J Acquir Immune Defic Syndr},
	volume = {59},
	year = {2012},
	month = {2012 Feb 1},
	pages = {121-5},
	abstract = {<p>The involvement of inflammasome genes in the susceptibility to HIV-1 infection was investigated. Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects and 158 healthy controls. The 2 polymorphisms rs10754558 in NLRP3 and rs1143634 in IL1B were significantly associated to the HIV-1 infection. These findings supported the previously hypothesized involvement of NALP3-inflammasome in HIV-1 pathogenesis, underlining once more the key role of inflammation and innate immunity in the susceptibility to HIV-1 infection.</p>},
	keywords = {Adaptor Proteins, Signal Transducing, Adult, Apoptosis Regulatory Proteins, Brazil, Calcium-Binding Proteins, CARD Signaling Adaptor Proteins, Carrier Proteins, Caspase 1, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, HIV Infections, HIV-1, Humans, Inflammasomes, Interleukin-1beta, Intracellular Signaling Peptides and Proteins, Male, Middle Aged, Neoplasm Proteins, Polymorphism, Single Nucleotide},
	issn = {1944-7884},
	doi = {10.1097/QAI.0b013e3182392ebe},
	author = {Pontillo, Alessandra and Oshiro, Telma M and Girardelli, Martina and Kamada, Anselmo J and Crovella, Sergio and Duarte, Alberto J S}
}
