@article {1931, title = {Gluten-dependent intestinal autoimmune response.}, journal = {Curr Pharm Des}, volume = {18}, year = {2012}, month = {2012}, pages = {5753-8}, abstract = {

Celiac disease is a multi-systemic autoimmune disease of the small bowel induced by gluten in genetically predisposed subjects. Highly specific and gluten-dependent production of auto-antibodies targeting self-proteins of the transglutaminase family occurs in the intestinal mucosa. These anti-transglutaminase antibodies are found deposited in intestinal and extra-intestinal tissue where they might exert biological effects, together with the intestinal mucosal gliadin-specific T lymphocytes. We conducted a brief review on antitransglutaminase antibodies effects, discussing their roles in the pathogenesis of several clinical manifestations of celiac disease.

}, keywords = {Animals, Autoantibodies, Celiac Disease, Genetic Predisposition to Disease, Gliadin, Glutens, Humans, Intestinal Mucosa, T-Lymphocytes, Transglutaminases}, issn = {1873-4286}, author = {Korponay-Szab{\'o}, Ilma Rita and Simon-Vecsei, Zsafia and De Leo, Luigina and Not, Tarcisio} }