@article {3626,
	title = {HLA-G and susceptibility to develop celiac disease.},
	journal = {Hum Immunol},
	volume = {76},
	year = {2015},
	month = {2015 Jan},
	pages = {36-41},
	abstract = {<p>The Human Leukocyte Antigen-G has immunomodulatory function and its expression has been associated with several diseases. In our study we analyzed HLA-G polymorphisms in order to evaluate their possible association with susceptibility to celiac disease development. A total of 420 celiac patients and 509 controls were genotyped for HLA-G polymorphisms. We sequenced 800bp upstream the ATG codon (5{\textquoteright} upstream regulatory region) and the whole 3{\textquoteright} untranslated region of the HLA-G gene, whereas the ΔC deletion at exon 3 was detected by RFLP-PCR. Five polymorphisms (namely -477 C>G, -369 C>A, 14bp del/ins, 3187 A>G, 3196 C>G) and one haplotype (TCGGTACGAAITCCCGAG) were significantly more frequent in celiac patients than controls and associated with increased disease susceptibility. The 14bp I/I, 3187 G/G, 3196 G/G genotypes and TCGGTACGAAITCCCGAG haplotype, were still significantly associated with increased disease susceptibility (and in addition also the 3003 C/C genotype) when the analysis was restricted to patients and controls presenting the DQ2.5 or DQ8 HLA-DQ celiac disease risk haplotypes. Our findings indicate an association between HLA-G gene polymorphisms and susceptibility to celiac disease development, suggesting that HLA-G molecule is possibly involved in the pathogenesis of the disease.</p>},
	keywords = {Adolescent, Adult, Alleles, Case-Control Studies, Celiac Disease, Child, Female, Gene Frequency, Genetic Predisposition to Disease, Haplotypes, HLA-DQ Antigens, HLA-G Antigens, Humans, Male, Middle Aged, Polymorphism, Genetic, Retrospective Studies},
	issn = {1879-1166},
	doi = {10.1016/j.humimm.2014.12.006},
	author = {Catamo, Eulalia and Zupin, Luisa and Segat, Ludovica and Celsi, Fulvio and Crovella, Sergio}
}
