@article {7683, title = {Lactotransferrin gene functional polymorphisms do not influence susceptibility to human immunodeficiency virus-1 mother-to-child transmission in different ethnic groups.}, journal = {Mem Inst Oswaldo Cruz}, volume = {110}, year = {2015}, month = {2015 Apr}, pages = {222-9}, abstract = {

Lactotransferrin, also known as lactoferrin, is an iron binding glycoprotein that displays antiviral activity against many different infectious agents, including human immunodeficiency virus (HIV)-1. Lactotransferrin is present in the breast milk and in the female genitourinary mucosa and it has been hypothesised as a possible candidate to prevent mother-to-child HIV-1 transmission. To verify if two functional polymorphisms, Thr29Ala and Arg47Lys, in the lactotransferrin encoding gene (LTF) could affect HIV-1 infection and vertical transmission, a preliminary association study was performed in 238 HIV-1 positive and 99 HIV-1 negative children from Brazil, Italy, Africa and India. No statistically significant association for the Thr29Ala and Arg47Lys LTF polymorphisms and HIV-1 susceptibility in the studied populations was found. Additionally LTF polymorphisms frequencies were compared between the four different ethnic groups.

}, keywords = {Acquired Immunodeficiency Syndrome, Adolescent, Brazil, Child, Cohort Studies, Ethnic Groups, Female, Gene Frequency, Genetic Predisposition to Disease, Genotyping Techniques, HIV-1, Humans, India, Infant, Newborn, Infectious Disease Transmission, Vertical, Italy, Lactoferrin, Male, Polymorphism, Single Nucleotide, Real-Time Polymerase Chain Reaction, Retrospective Studies, Zimbabwe}, issn = {1678-8060}, doi = {10.1590/0074-02760140447}, author = {Zupin, Luisa and Polesello, Vania and Coelho, Ant{\^o}nio Victor Campos and Boniotto, Michele and Arraes, Luiz Claudio and Segat, Ludovica and Crovella, Sergio} }