@article {8029,
	title = {Interleukin-18, interleukin-12B and interferon-γ gene polymorphisms in Brazilian patients with rheumatoid arthritis: a pilot study.},
	journal = {Tissue Antigens},
	volume = {86},
	year = {2015},
	month = {2015 Oct},
	pages = {276-8},
	abstract = {<p>Polymorphisms in interleukin (IL)-18, IL-12 and interferon (IFN)-γ genes are associated with different levels of cytokines expression and have been associated with rheumatoid arthritis (RA). IL-18 +105 A/C, IL-12B +1188 A/C and IFN-γ +874 T/A polymorphisms were analyzed by restriction fragment length polymorphism-polymerase chain reaction (PCR) and amplification refractory mutation system PCR from 90 RA patients and 186 healthy individuals. There were significant differences to IL-18 +105 A/C polymorphism between the RA and control groups (odds ratio = 3.77; P < 0.0001). Individual carriers of the variant allele C had a 3.77-fold increased risk of for RA (P = 0.0032). No association was observed for IL-12B and IFN-γ polymorphisms. Our finds suggest a possible role for IL-18 polymorphism in the RA susceptibility in studied population.</p>},
	issn = {1399-0039},
	doi = {10.1111/tan.12645},
	author = {Angelo, H D and Gomes Silva, I I F and Oliveira, R D R and Louzada-J{\'u}nior, P and Donadi, E A and Crovella, S and Maia, M M D and de Souza, P R E and Sandrin-Garcia, P}
}
