@article {8326,
	title = {CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: a case-control study.},
	journal = {Mem Inst Oswaldo Cruz},
	volume = {111},
	year = {2016},
	month = {2016 Mar},
	pages = {174-80},
	abstract = {<p>Polymorphisms in chemokine receptors play an important role in the progression of cervical intraepithelial neoplasia (CIN) to cervical cancer (CC). Our study examined the association of CCR2-64I (rs1799864) andCCR5-Δ32 (rs333) polymorphisms with susceptibility to develop cervical lesion (CIN and CC) in a Brazilian population. The genotyping of 139 women with cervical lesions and 151 women without cervical lesions for the CCR2-64I and CCR5-Δ32 polymorphisms were performed using polymerase chain reaction-restriction fragment length polymorphism. The individuals carrying heterozygous or homozygous genotypes (GA+AA) for CCR2-64I polymorphisms seem to be at lower risk for cervical lesion [odds ratio (OR) = 0.37, p = 0.0008)]. The same was observed for the A allele (OR = 0.39, p = 0.0002), while no association was detected (p > 0.05) with CCR5-Δ32 polymorphism. Regarding the human papillomavirus (HPV) type, patients carrying the CCR2-64Ipolymorphism were protected against infection by HPV type 16 (OR = 0.35, p = 0.0184). In summary, our study showed a protective effect ofCCR2-64I rs1799864 polymorphism against the development of cervical lesions (CIN and CC) and in the susceptibility of HPV 16 infection.</p>},
	issn = {1678-8060},
	doi = {10.1590/0074-02760150367},
	author = {Santos, Erinaldo Ubirajara Damasceno Dos and Lima, G{\'e}ssica Dayane Cordeiro de and Oliveira, Micheline de Lucena and Her{\'a}clio, Sandra de Andrade and Silva, Hildson Dornelas Angelo da and Crovella, Sergio and Maia, Maria de Mascena Diniz and Souza, Paulo Roberto Eleut{\'e}rio de}
}
