@article {10804, title = {Intranasal dexmedetomidine, as midazolam-sparing drug, for MRI in preterm neonates.}, journal = {Paediatr Anaesth}, volume = {28}, year = {2018}, month = {2018 08}, pages = {747-748}, issn = {1460-9592}, doi = {10.1111/pan.13454}, author = {Bua, Jenny and Massaro, Marta and Cossovel, Francesca and Monasta, Lorenzo and Brovedani, Pierpaolo and Cozzi, Giorgio and Barbi, Egidio and Demarini, Sergio and Travan, Laura} } @article {10846, title = {Secondary prevention of early-onset sepsis: a less invasive Italian approach for managing neonates at risk.}, journal = {Ital J Pediatr}, volume = {44}, year = {2018}, month = {2018 Jun 28}, pages = {73}, abstract = {

Strategies to prevent early-onset sepsis (EOS) have led to a substantial decline in many countries. However, one of the most controversial topics in neonatology is the management of asymptomatic full-term and late preterm neonates at risk for EOS, and guidelines lack substantial consensus regarding this issue. A strategy for managing neonates, entirely based on serial physical examinations, has been developed in two Italian regions. This strategy seems safe, while reducing laboratory tests and unnecessary antibiotics. In the current commentary we provide area-based data concerning the prevention of EOS in 2 northern Italian regions, and we detail the results of their strategy for managing healthy-appearing newborns at risk for EOS.

}, issn = {1824-7288}, doi = {10.1186/s13052-018-0515-8}, author = {Berardi, Alberto and Tzialla, Chryssoula and Travan, Laura and Bua, Jenny and Santori, Daniele and Azzalli, Milena and Spada, Caterina and Lucaccioni, Laura} } @article {10470, title = {Bolus feeding has no effect on cerebral hemodynamics, irrespective of gestational age.}, journal = {J Matern Fetal Neonatal Med}, volume = {30}, year = {2017}, month = {2017 May}, pages = {1029-1031}, abstract = {

OBJECTIVE: By multichannel near-infrared spectroscopy, we studied if gestational age has any influence on preterm cerebral hemodynamics, during bolus feeding.

METHODS: Oxy-haemoglobin (HbO), as cerebral blood flow estimate, and the ratio between HbO and total haemoglobin (HbO/HbTot), as cerebral oxygenation estimate, were assessed in 40 stable premature infants, during a 10 min bolus feeding.

RESULTS: We found no effect of any of the gestational ages studied (25-34 weeks) either on cerebral blood flow or on oxygenation, during a bolus feeding procedure.

CONCLUSIONS: Bolus feeding appears not to affect cerebral hemodynamics of uncritically preterm infants, irrespective of gestational age.

}, keywords = {Cerebrovascular Circulation, Enteral Nutrition, Female, Gestational Age, Heart Rate, Humans, Infant, Newborn, Infant, Premature, Intensive Care Units, Neonatal, Male, Oxygen, Oxyhemoglobins, Spectroscopy, Near-Infrared}, issn = {1476-4954}, doi = {10.1080/14767058.2016.1199672}, author = {Bembich, Stefano and Cont, Gabriele and Bua, Jenny and Orlando, Chiara and Di Benedetto, Donatella and Demarini, Sergio} } @article {10545, title = {Higher growth, fat and fat-free masses correlate with larger cerebellar volumes in preterm infants at term.}, journal = {Acta Paediatr}, volume = {106}, year = {2017}, month = {2017 Jun}, pages = {918-925}, abstract = {

AIM: Smaller cerebellar volumes in very low-birthweight (VLBW) infants at term have been related to adverse cognitive outcomes, and this study evaluated whether these volumes were associated with a growth in body composition during hospital stays.

METHODS: We prospectively recruited 42 VLBW infants from an Italian neonatal unit between January 2013 and August 2015. Cerebellar volumes and body composition were measured by magnetic resonance imaging (MRI) and air-displacement plethysmography, respectively, at 40 weeks of gestational age and anthropometric and nutritional data were collected. We also included 20 term-born controls.

RESULTS: The mean gestational age and birthweight of the VLBW infants were 29.4 ({\textpm}1.9) weeks and 1120 ({\textpm}290) g. There was a positive correlation between cerebellar volumes and daily weight gain from birth to term (R = 0.26, p = 0.001), weight (R = 0.25, p = 0.001), length (R = 0.16, p = 0.01), fat mass (R = 0.15, p = 0.01) and fat-free mass at term (R = 0.20, p = 0.003). In multiple regression analysis, daily weight gain, mechanical ventilation and postconceptional age at MRI were independently associated with cerebellar volumes. Anthropometric data and cerebellar volumes were similar between VLBW and control infants.

CONCLUSION: Higher growth, higher fat mass and fat-free mass were associated with larger cerebellar volumes in VLBW infants at term.

}, keywords = {Body Composition, Cerebellum, Child Development, Female, Humans, Infant, Newborn, Infant, Premature, Infant, Very Low Birth Weight, Male, Nutritional Status, Organ Size, Prospective Studies, Regression Analysis}, issn = {1651-2227}, doi = {10.1111/apa.13829}, author = {Paviotti, Giulia and De Cunto, Angela and Zennaro, Floriana and Boz, Giulia and Travan, Laura and Cont, Gabriele and Bua, Jenny and Demarini, Sergio} } @article {10496, title = {Theophylline increases diaphragmatic contractility in mechanically ventilated newborns.}, journal = {J Crit Care}, volume = {37}, year = {2017}, month = {2017 02}, pages = {264-265}, keywords = {Diaphragm, Humans, Infant, Newborn, Muscle Contraction, Theophylline}, issn = {1557-8615}, doi = {10.1016/j.jcrc.2016.10.001}, author = {De Cunto, Angela and Paviotti, Giulia and Bua, Jenny and Demarini, Sergio} } @article {7722, title = {Advising Mothers on the Use of Medications during Breastfeeding: A Need for a Positive Attitude.}, journal = {J Hum Lact}, year = {2015}, month = {2015 Jul 14}, abstract = {

The use of medications by the nursing mother is a common reason for interrupting breastfeeding. Few drugs have been demonstrated to be absolutely contraindicated during breastfeeding. Excessive caution may lead health professionals to unnecessarily advise to interrupt breastfeeding, without assessing the latest evidence or considering the risk-benefit ratio of taking a medication versus terminating breastfeeding. To foster an appropriate approach toward the use of medications in breastfeeding women, the Italian Society of Perinatal Medicine created the following policy statement.

}, issn = {1552-5732}, doi = {10.1177/0890334415595513}, author = {Davanzo, Riccardo and Bua, Jenny and De Cunto, Angela and Farina, Maria Luisa and De Ponti, Fabrizio and Clavenna, Antonio and Mandrella, Stefania and Sagone, Antonella and Clementi, Maurizio} } @article {3604, title = {Cerebral oxygenation with different nasal continuous positive airway pressure levels in preterm infants.}, journal = {Arch Dis Child Fetal Neonatal Ed}, volume = {100}, year = {2015}, month = {2015 Mar}, pages = {F165-8}, abstract = {

OBJECTIVES: This study evaluates the effect of varying nasal continuous positive airway pressure (NCPAP) level on cerebral blood flow (CBF) and oxygenation in preterm infants.

METHODS: Oxy-haemoglobin (HbO2) and total haemoglobin (HbTot), as CBF estimates, and the ratio between HbO2 and HbTot (HbO2/HbTot), as cerebral oxygenation estimate, were assessed by near-infrared spectroscopy in 26 stable preterm newborns at a postmenstrual age between 26 and 33 weeks. Baseline HbO2, HbTot and HbO2/HbTot values were initially collected with NCPAP at 5 cm H2O and then compared with values obtained with NCPAP levels at both 3 and 8 cm H2O.

RESULTS: Compared with 5 cm H2O, cerebral HbO2, HbTot and HbO2/HbTot remained unchanged both after increasing (to 8 cm H2O) and decreasing (to 3 cm H2O) the NCPAP level. This result was observed both in regional areas (24 sites) and in the overall monitored area (frontal and parietal cortex). Compared with 8 cm H2O, peripheral oxygen saturation significantly decreased at 3 cm H2O (p=0.021). Heart rate did not change.

CONCLUSIONS: No differences in CBF and cerebral oxygenation were observed with NCPAP levels in the range 3-8 cm H2O despite a decrease in peripheral oxygenation with 3 cm H2O.

}, keywords = {Cerebrovascular Circulation, Continuous Positive Airway Pressure, Female, Hemoglobins, Humans, Infant, Newborn, Infant, Premature, Intensive Care, Neonatal, Male, Nasal Cavity, Oxygen, Oxygen Consumption, Oxyhemoglobins, Spectroscopy, Near-Infrared}, issn = {1468-2052}, doi = {10.1136/archdischild-2014-306356}, author = {Bembich, Stefano and Travan, Laura and Cont, Gabriele and Bua, Jenny and Strajn, Tamara and Demarini, Sergio} } @article {7710, title = {Impact of Surgery for Neonatal Gastrointestinal Diseases on Weight and Fat Mass.}, journal = {J Pediatr}, volume = {167}, year = {2015}, month = {2015 Sep}, pages = {568-71}, abstract = {

OBJECTIVE: To compare growth, fat mass (FM), and fat-free mass in surgical infants vs matched controls at similar postconceptional age (PCA).

STUDY DESIGN: Anthropometric and body composition measurements by air-displacement plethysmography (PeaPod-Infant Body Composition System; LMI, Concord, California) were performed at the same PCA in 21 infants who received gastrointestinal surgery and in 21 controls matched for gestational age, birth weight, and sex.

RESULTS: Despite similar anthropometry at birth, postsurgical infants were shorter (50.4 [4.7] cm vs 53.2 [4.1] cm, P = .001), lighter (3516 [743] g vs 3946 [874] g, P < .001), and had lower FM content (\%FM 14.8 [4.7]\% vs 20.2 [5.8]\%, P < .0001) than their peers at similar PCA (43 [4] weeks). All surgical infants but 1 (20/21) received parenteral nutrition (PN). Mean PN duration was 40 (30) days. Five infants in the control group received PN because of prematurity for 15 (9-30) days. Nine infants in the surgical group and 1 in the control group had PN-associated cholestasis.

CONCLUSIONS: Neonates having surgery for gastrointestinal diseases were shorter, had lower weight, and lower FM content than their peers, despite receiving more PN. Body composition evaluation and monitoring may help optimize growth in these newborns.

}, issn = {1097-6833}, doi = {10.1016/j.jpeds.2015.06.013}, author = {De Cunto, Angela and Paviotti, Giulia and Travan, Laura and Bua, Jenny and Cont, Gabriele and Demarini, Sergio} } @article {7742, title = {Maternal holding vs oral glucose administration as nonpharmacologic analgesia in newborns: a functional neuroimaging study.}, journal = {JAMA Pediatr}, volume = {169}, year = {2015}, month = {2015 Mar}, pages = {284-5}, keywords = {Administration, Oral, Analgesia, Blood Specimen Collection, Female, Functional Neuroimaging, Glucose, Humans, Infant, Newborn, Mother-Child Relations, Pain, Pain Management, Spectroscopy, Near-Infrared}, issn = {2168-6211}, doi = {10.1001/jamapediatrics.2014.3052}, author = {Bembich, Stefano and Cont, Gabriele and Baldassi, Giulio and Bua, Jenny and Demarini, Sergio} } @article {3590, title = {Breastfeeding and migraine drugs.}, journal = {Eur J Clin Pharmacol}, volume = {70}, year = {2014}, month = {2014 Nov}, pages = {1313-24}, abstract = {

PURPOSE: Breastfeeding women may suffer from migraine. While we have many drugs for its treatment and prophylaxis, the majority are poorly studied in breastfeeding women. We conducted a review of the most common anti-migraine drugs (AMDs) and we determined their lactation risk.

METHODS: For each AMD, we collected all retrievable data from Hale{\textquoteright}s Medications and Mother Milk (2012), from the LactMed database (2014) of the National Library of Medicine, and from a MedLine Search of relevant studies published in the last 10 years.

RESULTS: According to our review, AMDs safe during breastfeeding are as follows: low-dose acetylsalicylic acid (ASA), ibuprofen, sumatriptan, metoprolol, propranolol, verapamil, amitriptyline, escitalopram, paroxetine, sertraline, acetaminophen, caffeine, and metoclopramide. AMDs compatible with breastfeeding but warranting caution are as follows: diclofenac, ketoprofen, naproxen, most new triptans, topiramate, valproate, venlafaxine, and cyproheptadine. Finally, high-dose ASA, atenolol, nadolol, cinnarizine, flunarizine, ergotamine, methysergide, and pizotifen are contraindicated.

CONCLUSIONS: According to our review, the majority of the revised AMDs were assessed to be compatible with breastfeeding.

}, keywords = {Adrenergic beta-Antagonists, Analgesics, Non-Narcotic, Animals, Anti-Inflammatory Agents, Non-Steroidal, Anticonvulsants, Antidepressive Agents, Breast Feeding, Calcium Channel Blockers, Female, Humans, Migraine Disorders, Tryptamines}, issn = {1432-1041}, doi = {10.1007/s00228-014-1748-0}, author = {Davanzo, Riccardo and Bua, Jenny and Paloni, Giulia and Facchina, Giulia} } @article {3496, title = {Can body mass index accurately predict adiposity in newborns?}, journal = {Arch Dis Child Fetal Neonatal Ed}, volume = {99}, year = {2014}, month = {2014 May}, pages = {F238-9}, abstract = {

Body mass index (BMI) is correlated with body fatness and risk of related diseases in children and adults. Proportionality indexes such as BMI and ponderal index (PI) have been suggested as complementary measures in neonatal growth assessment. Yet, they are still not used in neonates and their correlation with fatness is unknown. The aim of the study was to test the hypothesis that BMI z-score would predict neonatal adiposity. Body composition measurements (ie, fat mass, fat-free mass) by air displacement plethysmography (PEA POD, LMI, Concord-USA), weight and length were obtained in 200 infants >=36 weeks{\textquoteright} gestational age (GA) at birth. Linear regression analysis showed a direct association between BMI z-score and \%fat mass (r(2)=0.43, p<0.0001). This association was confirmed independently from sex, GA and maternal prepregnancy BMI. BMI z-score predicted adiposity better than PI. However, both BMI z-score and PI were poor predictors of adiposity at birth.

}, keywords = {Adiposity, Adult, Anthropometry, Body Composition, Body Mass Index, Cross-Sectional Studies, Female, Gestational Age, Humans, Infant, Newborn, Male, Mothers, Plethysmography, Predictive Value of Tests, Regression Analysis, Reproducibility of Results, Sex Factors}, issn = {1468-2052}, doi = {10.1136/archdischild-2013-305386}, author = {De Cunto, Angela and Paviotti, Giulia and Ronfani, Luca and Travan, Laura and Bua, Jenny and Cont, Gabriele and Demarini, Sergio} } @article {3534, title = {High-frequency percussive ventilation as rescue treatment in severe hypoxemic respiratory failure in term neonates.}, journal = {J Crit Care}, volume = {29}, year = {2014}, month = {2014 Aug}, pages = {662-3}, keywords = {Female, High-Frequency Ventilation, Humans, Male, Oxygen, Pulmonary Gas Exchange, Respiratory Insufficiency}, issn = {1557-8615}, doi = {10.1016/j.jcrc.2014.02.018}, author = {Paviotti, Giulia and Bua, Jenny and De Cunto, Angela and Travan, Laura and Demarini, Sergio} } @article {1902, title = {Management of cryptorchidism: a survey of clinical practice in Italy.}, journal = {BMC Pediatr}, volume = {12}, year = {2012}, month = {2012}, pages = {4}, abstract = {

BACKGROUND: An evidence-based Consensus on the treatment of undescended testis (UT) was recently published, recommending to perform orchidopexy between 6 and 12 months of age, or upon diagnosis and to avoid the use of hormones. In Italy, current practices on UT management are little known. Our aim was to describe the current management of UT in a cohort of Italian children in comparison with the Consensus guidelines. As management of retractile testis (RT) differs, RT cases were described separately.

METHODS: Ours is a retrospective, multicenter descriptive study. An online questionnaire was filled in by 140 Italian Family Paediatricians (FP) from Associazione Culturale Pediatri (ACP), a national professional association of FP. The questionnaire requested information on all children with cryptorchidism born between 1/01/2004 and 1/01/2006. Data on 169 children were obtained. Analyses were descriptive.

RESULTS: Overall 24\% of children were diagnosed with RT, 76\% with UT. Among the latter, cryptorchidism resolved spontaneously in 10\% of cases at a mean age of 21.6 months. Overall 70\% of UT cases underwent orchidopexy at a mean age of 22.8 months (SD 10.8, range 1.2-56.4), 13\% of whom before 1 year. The intervention was performed by a paediatric surgeon in 90\% of cases, with a success rate of 91\%. Orchidopexy was the first line treatment in 82\% of cases, while preceded by hormonal treatment in the remaining 18\%. Hormonal treatment was used as first line therapy in 23\% of UT cases with a reported success rate of 25\%. Overall, 13 children did not undergo any intervention (mean age at last follow up 39.6 months). We analyzed the data from the 5 Italian Regions with the largest number of children enrolled and found a statistically significant regional difference in the use of hormonal therapy, and in the use of and age at orchidopexy.

CONCLUSIONS: Our study showed an important delay in orchidopexy. A quarter of children with cryptorchidism was treated with hormonal therapy. In line with the Consensus guidelines, surgery was carried out by a paediatric surgeon in the majority of cases, with a high success rate.

}, keywords = {Child, Preschool, Chorionic Gonadotropin, Cryptorchidism, Gonadotropin-Releasing Hormone, Guideline Adherence, Humans, Infant, Italy, Male, Middle Aged, Orchiopexy, Pediatrics, Physician{\textquoteright}s Practice Patterns, Practice Guidelines as Topic, Questionnaires, Retrospective Studies, Treatment Outcome}, issn = {1471-2431}, doi = {10.1186/1471-2431-12-4}, author = {Marchetti, Federico and Bua, Jenny and Tornese, Gianluca and Piras, Gianni and Toffol, Giacomo and Ronfani, Luca} } @article {1782, title = {Neonatal necrotizing tracheobronchitis.}, journal = {J Pediatr}, volume = {159}, year = {2011}, month = {2011 Oct}, pages = {699-699.e1}, keywords = {Bronchitis, Bronchoscopy, High-Frequency Ventilation, Humans, Infant, Newborn, Male, Necrosis, Respiratory Insufficiency, Respiratory Mucosa, Tracheitis}, issn = {1097-6833}, doi = {10.1016/j.jpeds.2011.04.043}, author = {Bua, Jenny and Trappan, Antonella and Demarini, Sergio and Grasso, Domenico and Schleef, Jurgen and Zennaro, Floriana} } @article {1629, title = {Hepatic glycogenosis in an adolescent with diabetes.}, journal = {J Pediatr}, volume = {157}, year = {2010}, month = {2010 Dec}, pages = {1042}, keywords = {Adolescent, Diabetes Mellitus, Type 1, Female, Glycogen Storage Disease, Humans, Liver Diseases}, issn = {1097-6833}, doi = {10.1016/j.jpeds.2010.06.018}, author = {Bua, Jenny and Marchetti, Federico and Faleschini, Elena and Ventura, Alessandro and Bussani, Rossana} }