@article {10756, title = {Anaphylaxis in atypical cold urticaria: case report and review of literature.}, journal = {Ital J Pediatr}, volume = {44}, year = {2018}, month = {2018 Nov 13}, pages = {135}, abstract = {

BACKGROUND: Cold-induced urticaria is a kind of physical urticaria characterized by the appearance of wheals after exposure to cold. The atypical form is a rare sub-type characterized by appearance of hives even in areas not directly exposed to the cold and by a negative cold stimulation test. Its diagnosis is often challenging because of the lack of specific tests and it is usually based on the patient{\textquoteright}s clinical history. Hypotension due to generalized exposure to the cold is described both in the typical and the atypical forms.

CASE PRESENTATION: We describe a 9-year-old boy who, at the beginning of the summer after the first swim in the sea, developed generalized urticaria, dyspnea, conjunctival hyperemia, blurred vision and loss of strength. The child was treated with intramuscular steroid and intravenous antihistamine, and the symptoms quickly resolved. Insect bite, contact with fish and drug ingestion were denied, and no unusual food had been eaten before the swim. A tentative diagnosis was made of either aquagenic urticaria or cold urticaria, but the specific tests were negative. Although the cause was unknown, prophylactic treatment with antihistamines was prescribed but in spite of this, wheals developed all over the body, after every swim in the sea. The child then came to our attention and relying on clinical history a diagnosis of atypical cold urticaria was made: development of hives even in areas not directly exposed to cold and a negative response to the cold stimulation test, are the characteristic features of this rare form of cold urticaria.

CONCLUSION: Atypical cold urticaria should be suspected in all cases of anaphylaxis related to cold exposure (i.e. contact with water) with a negative cold stimulation test.

}, keywords = {Anaphylaxis, Child, Cold Temperature, Humans, Male, Swimming, Urticaria}, issn = {1824-7288}, doi = {10.1186/s13052-018-0578-6}, author = {Benelli, Elisa and Longo, Giorgio and Barbi, Egidio and Berti, Irene} } @article {10800, title = {Inclusion cyst of anterior fontanelle.}, journal = {Arch Dis Child}, year = {2018}, month = {2018 Aug 21}, issn = {1468-2044}, doi = {10.1136/archdischild-2018-315727}, author = {Udina, Chiara and Calligaris, Lorenzo and Berti, Irene and Cattaruzzi, Elisabetta and Barbi, Egidio} } @article {10498, title = {Safety and effectiveness of oral propranolol for infantile hemangiomas started before 5~weeks and after 5~months of age: an Italian multicenter experience.}, journal = {Ital J Pediatr}, volume = {43}, year = {2017}, month = {2017 Apr 19}, pages = {40}, abstract = {

BACKGROUND: Despite not being licensed for the treatment of infantile hemangiomas (IH) in infants younger than 5~weeks or older than 5~months, propranolol is often used in these age groups to prevent or to treat potentially severe complications. The objective of the present study was to review the experience of 8 Italian pediatric and dermatologic centers regarding propranolol treatment for IH started before 5~weeks or after 5~months of age.

METHODS: We retrospectively reviewed the records of patients followed up for IH, on propranolol treatment started before 5~weeks or after 5~months of age, and collected information on sociodemographic data, treatment indications, IH involution, IH relapse, and treatment side effects.

RESULTS: A total of 343 patients were enrolled; 15 were started on propranolol before 5~weeks (group 1), 328 were started after 5~months of age (group 2). The most frequent indications were permanent aesthetical disfigurement (91.8\%) and function threatening complications (42.6\%). In most cases, the treatment was effective. The involution was partial in 67.7\% of patients. In 11.8\% of cases a relapse was observed. No relapse was observed in group 1. Treatment complications were reported in 15.8\% of children, most frequently sleep disorders (6.6\%), followed by irritability (5.1\%) and diarrhea (2.2\%). Only a case of mild constipation was observed in group 1.

CONCLUSION: The safety and effectiveness profile of propranolol in infants younger than 5~weeks or older than 5~months may be acceptable. Taking in account propranolol{\textquoteright}s potential in preventing severe complications, further studies should assess the acceptability of propranolol treatment, especially in the <5-week age group .

}, keywords = {Administration, Oral, Age Factors, Cohort Studies, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Hemangioma, Humans, Infant, Infant, Newborn, Italy, Male, Patient Safety, Propranolol, Retrospective Studies, Skin Neoplasms, Treatment Outcome}, issn = {1824-7288}, doi = {10.1186/s13052-017-0357-9}, author = {El Hachem, Maya and Gesualdo, Francesco and Diociaiuti, Andrea and Berti, Irene and Vercellino, Nadia and Boccaletti, Valeria and Neri, Iria and Porcedda, Giulio and Greco, Antonella and Carnevale, Claudia and Oranges, Teresa and Cutrone, Mario and Dalmonte, Pietro} } @article {8292, title = {Subcutaneous Granuloma Annulare: A Diagnostic Conundrum-Learning From Mistakes.}, journal = {Pediatr Emerg Care}, volume = {33}, year = {2017}, month = {2017 Aug}, pages = {e30-e31}, abstract = {

Subcutaneous granuloma annulare is an inflammatory lesion occurring in otherwise healthy children. We present 3 pediatric patients with different diagnostic-therapeutic paths depending on the ward they were referred to. The lesions regress spontaneously, and medical or surgical treatments are generally not necessary.

}, keywords = {Arm, Child, Preschool, Connective Tissue Diseases, Diagnosis, Differential, Female, Granuloma Annulare, Humans, Infant, Leg, Male, Ultrasonography, Doppler, Color}, issn = {1535-1815}, doi = {10.1097/PEC.0000000000000591}, author = {Pederiva, Federica and Paloni, Giulia and Berti, Irene} } @article {8318, title = {Consensus Conference on Clinical Management of pediatric Atopic Dermatitis.}, journal = {Ital J Pediatr}, volume = {42}, year = {2016}, month = {2016}, pages = {26}, abstract = {

The Italian Consensus Conference on clinical management of atopic dermatitis in children reflects the best and most recent scientific evidence, with the aim to provide specialists with a useful tool for managing this common, but complex clinical condition. Thanks to the contribution of experts in the field and members of the Italian Society of Pediatric Allergology and Immunology (SIAIP) and the Italian Society of Pediatric Dermatology (SIDerP), this Consensus statement integrates the basic principles of the most recent guidelines for the management of atopic dermatitis to facilitate a practical approach to the disease. The therapeutical approach should be adapted to the clinical severity and requires a tailored strategy to ensure good compliance by children and their parents. In this Consensus, levels and models of intervention are also enriched by the Italian experience to facilitate a practical approach to the disease.

}, issn = {1824-7288}, doi = {10.1186/s13052-016-0229-8}, author = {Galli, Elena and Neri, Iria and Ricci, Giampaolo and Baldo, Ermanno and Barone, Maurizio and Belloni Fortina, Anna and Bernardini, Roberto and Berti, Irene and Caffarelli, Carlo and Calamelli, Elisabetta and Capra, Lucetta and Carello, Rossella and Cipriani, Francesca and Comberiati, Pasquale and Diociaiuti, Andrea and El Hachem, Maya and Fontana, Elena and Gruber, Michaela and Haddock, Ellen and Maiello, Nunzia and Meglio, Paolo and Patrizi, Annalisa and Peroni, Diego and Scarponi, Dorella and Wielander, Ingrid and Eichenfield, Lawrence F} } @article {3621, title = {"Blaschkoid dyspigmentation" in a child: don{\textquoteright}t forget fibroblast chromosomal analysis.}, journal = {J Pediatr}, volume = {166}, year = {2015}, month = {2015 Feb}, pages = {490-90.e1}, keywords = {Abnormalities, Multiple, Child, Preschool, Chromosomes, DNA, Female, Fibroblasts, Humans, Phenotype, Pigmentation Disorders}, issn = {1097-6833}, doi = {10.1016/j.jpeds.2014.10.028}, author = {Gortani, Giulia and Faletra, Flavio and Bruno, Irene and Berti, Irene and Ventura, Alessandro} } @article {7776, title = {Legius syndrome: case report and review of literature.}, journal = {Ital J Pediatr}, volume = {41}, year = {2015}, month = {2015}, pages = {8}, abstract = {

A 8-month-old child was referred to our Dermatologic Unit for suspected Neurofibromatosis type 1 (NF 1), because of the appearance, since few days after birth, of numerous caf{\'e}-au-lait spots (seven larger than 5 mm); no other sign evocative of NF 1 was found. Her family history was remarkable for the presence of multiple caf{\'e}-au-lait spots in the mother, the grandfather and two aunts. The family had been already examined for NF 1, but no sign evocative of the disease was found. We then suspected Legius syndrome, a dominant disease characterized by a mild neurofibromatosis 1 phenotype. The diagnosis was confirmed by the finding of a mutation in SPRED1 gene, a feedback regulator of RAS/MAPK signaling. Here, we discuss the differential diagnosis of caf{\`e}-au-lait spots and we briefly review the existing literature about Legius syndrome.

}, issn = {1824-7288}, doi = {10.1186/s13052-015-0115-9}, author = {Benelli, Elisa and Bruno, Irene and Belcaro, Chiara and Ventura, Alessandro and Berti, Irene} } @article {7734, title = {Phleboliths as a marker of slow-flow venous malformation.}, journal = {Arch Dis Child}, volume = {100}, year = {2015}, month = {2015 Nov}, pages = {1012}, issn = {1468-2044}, doi = {10.1136/archdischild-2015-308935}, author = {Calligaris, Lorenzo and Berti, Irene and Barbi, Egidio} } @article {8064, title = {Tinea Incognito.}, journal = {J Pediatr}, volume = {167}, year = {2015}, month = {2015 Dec}, pages = {1450-1450.e2}, issn = {1097-6833}, doi = {10.1016/j.jpeds.2015.08.062}, author = {Paloni, Giulia and Valerio, Enrico and Berti, Irene and Cutrone, Mario} } @article {3493, title = {Cow{\textquoteright}s milk allergy in children, from avoidance to tolerance.}, journal = {Endocr Metab Immune Disord Drug Targets}, volume = {14}, year = {2014}, month = {2014 Mar}, pages = {47-53}, abstract = {

Food allergy is the primary cause of anaphylaxis in paediatric age affecting roughly 4\% of children and their families worldwide, and requiring changes in dietary habits. The prognosis for food allergy in children has traditionally been regarded as good for the most frequent allergens, however the prognosis for cow{\textquoteright}s milk allergy in the pediatric age is currently considered to be worse than previously believed. There is now enough evidence that measures of avoidance for children at risk did not have any preventive effect whatsoever, but they still came to be counterproductive by avoiding the physiological interaction between food allergens and gastrointestinal mucosal immune system. Programs of specific oral tolerance induction (SOTI) have obtained interesting results in the treatment of food allergy supporting the idea that antigen exposure through gastrointestinal section is important to allow the development of tolerance. Nevertheless this approach is not yet considered "ready" for community recommendations. In this paper we describe our experience in the field of SOTI in children with cow{\textquoteright}s milk allergy.

}, keywords = {Animals, Cattle, Child, Child, Preschool, Desensitization, Immunologic, Humans, Immune Tolerance, Milk Hypersensitivity, Milk Substitutes, Retrospective Studies}, issn = {2212-3873}, author = {Calligaris, Lorenzo and Longo, Giorgio and Badina, Laura and Berti, Irene and Barbi, Egidio} } @article {1970, title = {Acropustulosis of infancy.}, journal = {Arch Dis Child Fetal Neonatal Ed}, volume = {98}, year = {2013}, month = {2013 Jul}, pages = {F340}, keywords = {Acrodermatitis, Diagnosis, Differential, Female, Foot Dermatoses, Hand Dermatoses, Humans, Infant, Newborn}, issn = {1468-2052}, doi = {10.1136/archdischild-2012-302685}, author = {Paloni, Giulia and Berti, Irene and Cutrone, Mario} } @article {1974, title = {Under pressure.}, journal = {Eur J Pediatr}, volume = {172}, year = {2013}, month = {2013 Mar}, pages = {417}, abstract = {

Physical urticaria is a rare but challenging subset of chronic urticaria. Wheals of pressure urticaria are typically delayed in appearance. A pressure test can easily be done to confirm the diagnosis.

}, keywords = {Child, Humans, Male, Pressure, Urticaria}, issn = {1432-1076}, doi = {10.1007/s00431-012-1819-0}, author = {De Cunto, Angela and Berti, Irene and Minute, Marta and Longo, Giorgio} } @article {1935, title = {The dietary paradox in food allergy: yesterday{\textquoteright}s mistakes, today{\textquoteright}s evidence and lessons for tomorrow.}, journal = {Curr Pharm Des}, volume = {18}, year = {2012}, month = {2012}, pages = {5782-7}, abstract = {

During the last decades the prevalence of food allergy has significantly increased among children and antigen avoidance still remains the standard care for the management of this condition. Most reactions are IgE-mediated with a high risk of anaphylaxis requiring emergency medications in case of inadvertent ingestion. Recent studies showed that continuous administration of the offending food, rather than an elimination diet, could promote the development and maintenance of oral tolerance. Indeed, intestinal transit of food proteins and their interaction with gut-associated lymphoid tissue (GALT) is the essential prerequisite for oral tolerance. On the contrary, low-dose cutaneous exposure to environmental foods in children with atopic dermatitis and altered skin barrier facilitates allergic sensitization. The timing and the amount of cutaneous and oral exposure determine whether a child will have allergy or tolerance. Furthermore, previous preventive strategies such as the elimination diet during pregnancy and breastfeeding, prolonged exclusive breastfeeding and delayed weaning to solid foods did not succeed in preventing the development of food allergy. On the other hand, there could be an early narrow window of immunological opportunity to expose children to allergenic foods and induce natural tolerance. Finally, the gradual exposure to the offending food through special protocols of specific oral tolerance induction (SOTI) may be a promising approach to a proactive treatment of food allergy.

}, keywords = {Anaphylaxis, Antigens, Breast Feeding, Child, Dermatitis, Atopic, Female, Food Hypersensitivity, Humans, Immunoglobulin E, Pregnancy, Time Factors}, issn = {1873-4286}, author = {Badina, Laura and Barbi, Egidio and Berti, Irene and Radillo, Oriano and Matarazzo, Lorenza and Ventura, Alessandro and Longo, Giorgio} } @article {1966, title = {A red baby should not be taken too lightly.}, journal = {Acta Paediatr}, volume = {101}, year = {2012}, month = {2012 Dec}, pages = {e573-7}, abstract = {

AIM: To identify clinical and laboratory features that can drive the differential diagnosis of a primary immunodeficiency diseases in patients with ectodermal defects.

METHODS: Analysis of selected teaching cases.

RESULTS: We identified four exemplary cases that allowed to point out specific clues.

CONCLUSIONS: A careful evaluation of immune and ectodermal signs is the key to the diagnosis. Therefore, a multidisciplinary approach can lead to diagnosis and to an appropriate treatment in most of the cases.

}, keywords = {Child, Preschool, Dermatitis, Ectodermal Dysplasia, Female, Humans, Immunologic Deficiency Syndromes, Infant, Male, Netherton Syndrome, Severe Combined Immunodeficiency, Skin}, issn = {1651-2227}, doi = {10.1111/apa.12018}, author = {Faletra, Flavio and Bruno, Irene and Berti, Irene and Pastore, Serena and Pirrone, Angela and Tommasini, Alberto} } @article {1886, title = {RICH (rapidly involuting congenital hemangioma): not only a definition of wealth.}, journal = {J Pediatr}, volume = {161}, year = {2012}, month = {2012 Aug}, pages = {365-365.e1}, keywords = {Female, Hemangioma, Humans, Infant, Newborn, Skin Neoplasms}, issn = {1097-6833}, doi = {10.1016/j.jpeds.2012.02.036}, author = {Abate, Maria Valentina and Davanzo, Riccardo and Bibalo, Chiara and Zennaro, Floriana and Berti, Irene} } @article {1827, title = {Successful induction of oral tolerance in Netherton syndrome.}, journal = {Allergol Immunopathol (Madr)}, volume = {40}, year = {2012}, month = {2012 Sep-Oct}, pages = {316-7}, keywords = {Allergens, Alopecia, Child, Preschool, Desensitization, Immunologic, Disease-Free Survival, Eczema, Female, Food Hypersensitivity, Hair Follicle, Humans, Immune Tolerance, Immunoglobulin E, Infant, Newborn, Mouth, Netherton Syndrome, Treatment Outcome}, issn = {1578-1267}, doi = {10.1016/j.aller.2011.07.005}, author = {Pastore, Serena and Gorlato, Gaia and Berti, Irene and Barbi, Egidio and Ventura, Alessandro} } @article {1604, title = {Successful treatment of acne with isotretinoin in chronic granulomatous disease.}, journal = {Eur J Dermatol}, volume = {21}, year = {2011}, month = {2011 Jan-Feb}, pages = {111-2}, keywords = {Acne Vulgaris, Adult, Anti-Infective Agents, Comorbidity, Dermatologic Agents, Granulomatous Disease, Chronic, Humans, Isotretinoin, Male, Trimethoprim-Sulfamethoxazole Combination}, issn = {1167-1122}, doi = {10.1684/ejd.2010.1171}, author = {Barbi, Egidio and Berti, Irene and Minute, Marta and Zennaro, Floriana} }