@article {8091, title = {Unusual onset of a case of chronic recurrent multifocal osteomyelitis.}, journal = {Pediatr Rheumatol Online J}, volume = {13}, year = {2015}, month = {2015}, pages = {60}, abstract = {

BACKGROUND: Chronic recurrent multifocal osteomyelitis (CRMO) is a rare condition that commonly affects the clavicle and pelvis.

CASE PRESENTATION: We report here a case a 12~years old girl with CRMO arising with recurrent episodes of left supraorbital headache, followed by the appearance of a periorbital dyschromia. Magnetic resonance imaging (MRI) of the skull and orbits revealed an important subacute inflammatory process. Few months after, the child presented a painful swelling of the left clavicle; the histological examination of the related biopsy allowed to establish the diagnosis of CRMO.

CONCLUSION: CRMO presenting as acute headache involving neurocranium is rare; to our knowledge this is the first recognized case in the world literature. This pathological condition is frequently misdiagnosed as infection or neoplasm and needs a deep investigation for the differential diagnosis. The physical, laboratoristic and instrumental diagnostic investigations of the patient and the treatment employed are described in detail.

}, issn = {1546-0096}, doi = {10.1186/s12969-015-0058-0}, author = {Barrani, M and Massei, F and Scaglione, M and Paolicchi, A and Vitali, S and Ciancia, E M and Crovella, S and Caparello, M C and Consolini, R} }