@article {8509, title = {A Child with Severe Developmental Delay and Growth Retardation.}, journal = {J Pediatr}, volume = {175}, year = {2016}, month = {2016 Aug}, pages = {241-241.e1}, issn = {1097-6833}, doi = {10.1016/j.jpeds.2016.05.006}, author = {Rossetto, Elena and Matarazzo, Lorenza and Maschio, Massimo and Taddio, Andrea and Costa, Paola and Ventura, Alessandro} } @article {8489, title = {The Great Pretender: Pediatric Wandering Spleen: Two Case Reports and Review of the Literature.}, journal = {Pediatr Emerg Care}, year = {2016}, month = {2016 Feb 10}, abstract = {

Wandering spleen is a rare condition, typically not only due to embryological defects of the splenic ligaments, but also secondary to trauma and splenomegaly. The most common presentation is acute abdomen with a mobile abdominal mass or recurrent abdominal pain. However, the spleen may be temporary in its normal position, and patients could be asymptomatic. A familiarity, if present, strengthens the diagnostic suspect.Abdominal ultrasonography and computed tomography are the examination of choice, and the management is surgical.

}, issn = {1535-1815}, doi = {10.1097/PEC.0000000000000642}, author = {Radillo, Lucia and Taddio, Andrea and Ghirardo, Sergio and Bramuzzo, Matteo and Pederiva, Federica and Maschio, Massimo and Barbi, Egidio} } @article {7708, title = {Effect of Thalidomide on Clinical Remission in Children and Adolescents with Ulcerative Colitis Refractory to Other Immunosuppressives: Pilot Randomized Clinical Trial.}, journal = {Inflamm Bowel Dis}, volume = {21}, year = {2015}, month = {2015 Aug}, pages = {1739-49}, abstract = {

BACKGROUND: In a randomized controlled trial, thalidomide has shown to be effective in refractory Crohn{\textquoteright}s disease in children. This pilot study aimed at evaluating thalidomide in refractory pediatric ulcerative colitis (UC).

METHODS: Double-blind, placebo-controlled randomized clinical trial on thalidomide 1.5 to 2.5 mg/kg/day in children with active UC despite multiple immunosuppressive treatments. In an open-label extension, nonresponders to placebo received thalidomide for an additional 8 weeks; all responders were followed up for a minimum of 52 weeks.

RESULTS: Twenty-six children with refractory UC were randomized to thalidomide or placebo. Clinical remission at week 8 was achieved by significantly more children treated with thalidomide {10/12 (83.3\%) versus 2/11 (18.8\%); risk ratio, 4.5 (95\% confidence interval [CI], 1.2-16.4); P = 0.005; number needed to treat, 1.5}. Of the nonresponders to placebo who were switched to thalidomide, 8 of 11 (72.7\%) subsequently reached remission at week 8 (risk ratio, 4.0 [95\% CI, 1.1-14.7]; number needed to treat, 2.45; P = 0.01). Clinical remission in the thalidomide group was 135.0 weeks (95\% CI, 32-238), compared with 8.0 weeks (95\% CI, 2.4-13.6) in the placebo group (P < 0.0001). Cumulative incidence of severe adverse events was 3.1 per 1000 patient-weeks. Peripheral neuropathy and amenorrhea were the most frequent adverse events.

CONCLUSIONS: In this pilot randomized controlled trial on cases of UC refractory to immunosuppressive therapy, thalidomide compared with placebo resulted in improved clinical remission at 8 weeks of treatment and in longer term maintenance of remission. These findings require replication in larger clinical studies evaluating both thalidomide efficacy and safety.

}, issn = {1536-4844}, doi = {10.1097/MIB.0000000000000437}, author = {Lazzerini, Marzia and Martelossi, Stefano and Magazz{\`u}, Giuseppe and Pellegrino, Salvatore and Lucanto, Maria Cristina and Barabino, Arrigo and Calvi, Angela and Arrigo, Serena and Lionetti, Paolo and Lorusso, Monica and Mangiantini, Francesca and Fontana, Massimo and Zuin, Giovanna and Palla, Gabriella and Maggiore, Giuseppe and Bramuzzo, Matteo and Pellegrin, Maria Chiara and Maschio, Massimo and Villanacci, Vincenzo and Manenti, Stefania and Decorti, Giuliana and De Iudicibus, Sara and Paparazzo, Rossella and Montico, Marcella and Ventura, Alessandro} } @article {7761, title = {Extremely large air distension of the bowel.}, journal = {Lancet}, volume = {385}, year = {2015}, month = {2015 Jun 13}, pages = {2399}, keywords = {Adolescent, Air, Biopsy, Female, Hirschsprung Disease, Humans, Intestine, Large, Rectum}, issn = {1474-547X}, doi = {10.1016/S0140-6736(14)61901-2}, author = {Pavan, Matteo and Ventura, Giovanna and Maschio, Massimo and Ventura, Alessandro} } @article {8048, title = {Handlebar injury in children: The~hidden danger.}, journal = {Surgery}, year = {2015}, month = {2015 Sep 18}, issn = {1532-7361}, doi = {10.1016/j.surg.2015.08.009}, author = {Pederiva, Federica and Guida, Edoardo and Maschio, Massimo and Rigamonti, Waifro and Gregori, Massimo and Codrich, Daniela} } @article {7759, title = {Serum anti-tissue transglutaminase antibodies detected during febrile illness may not be produced by the intestinal mucosa.}, journal = {J Pediatr}, volume = {166}, year = {2015}, month = {2015 Mar}, pages = {761-3}, abstract = {

Anti-transglutaminase antibodies are the diagnostic marker of celiac disease, and are considered to be synthesized only by intestinal B-lymphocytes. During an infectious disease, these antibodies are transiently detected in serum. We show that these infection-triggered antibodies may not originate in the intestinal mucosa and are not an indication of celiac disease.

}, keywords = {Autoantibodies, Celiac Disease, Child, Preschool, Diagnosis, Differential, Enzyme-Linked Immunosorbent Assay, Female, GTP-Binding Proteins, Humans, Intestinal Mucosa, Male, Transglutaminases}, issn = {1097-6833}, doi = {10.1016/j.jpeds.2014.12.005}, author = {De Leo, Luigina and Quaglia, Sara and Ziberna, Fabiana and Vatta, Serena and Martelossi, Stefano and Maschio, Massimo and Not, Tarcisio} } @article {7747, title = {Three cases of Bartonella quintana infection in children.}, journal = {Pediatr Infect Dis J}, volume = {34}, year = {2015}, month = {2015 May}, pages = {540-2}, abstract = {

We present 3 children affected by B. quintana infection treated at the IRCCS Burlo Garofolo of Trieste between March and April 2013. B. quintana infection is rare but it should be suspected in patients with fever and lymphadenopathy who do not respond to conventional antibiotic treatment. All patients had a complete recovery without sequelae or relapses.

}, issn = {1532-0987}, doi = {10.1097/INF.0000000000000666}, author = {Magnolato, Andrea and Pederiva, Federica and Spagnut, Giulia and Maschio, Massimo and Ventura, Alessandro and Taddio, Andrea} } @article {3569, title = {Multiple Ileo-Ileal Intussusceptions Caused by Eosinophilic Enteropathy.}, journal = {J Pediatr Gastroenterol Nutr}, year = {2014}, month = {2014 Jul 2}, issn = {1536-4801}, doi = {10.1097/MPG.0000000000000479}, author = {Bramuzzo, Matteo and Martelossi, Stefano and Villanacci, Vincenzo and Maschio, Massimo and Costa, Stefano and Ventura, Alessandro} } @article {1962, title = {A boy with acute strabismus.}, journal = {J Pediatr}, volume = {161}, year = {2012}, month = {2012 Dec}, pages = {1178}, keywords = {Acute Disease, Child, Humans, Magnetic Resonance Imaging, Male, Mucocele, Strabismus}, issn = {1097-6833}, doi = {10.1016/j.jpeds.2012.06.055}, author = {Poropat, Federico and Ventura, Giovanna and Murru, Flora M and Orzan, Eva and Maschio, Massimo} } @article {1951, title = {A child with edema, lower limb deformity, and recurrent diarrhea.}, journal = {J Pediatr}, volume = {161}, year = {2012}, month = {2012 Dec}, pages = {1177}, keywords = {Bone Retroversion, Capsule Endoscopy, Child, Preschool, Diarrhea, Edema, Humans, Knee Joint, Lymphangiectasis, Intestinal, Lymphedema, Male, Recurrence}, issn = {1097-6833}, doi = {10.1016/j.jpeds.2012.06.022}, author = {Gortani, Giulia and Maschio, Massimo and Ventura, Alessandro} } @article {1816, title = {Thromboembolism in pediatric inflammatory bowel disease: systematic review.}, journal = {Inflamm Bowel Dis}, volume = {17}, year = {2011}, month = {2011 Oct}, pages = {2174-83}, abstract = {

BACKGROUND: Several studies suggest an increased risk of venous and arterial thromboembolism (TE) in adults with inflammatory bowel disease (IBD) compared to the general population. We performed a systematic review of studies on incidence and characteristic of TE in children with IBD.

METHODS: We searched Medline, LILACS, EMBASE, POPLINE, CINHAL, and reference lists of identified articles, without language restrictions, in August 2010.

RESULTS: Population studies suggest that there is an increased risk of TE in children with IBD compared to controls. TE occurred in children with IBD in all age ranges, mostly (82.8\%) during active disease, and more frequently in children with ulcerative colitis (odds ratio [OR] 3.7, 95\% confidence interval [CI] 1.8-7.6). At least one specific risk factor for TE was recognized in 50\% of cases; two risk factors were present in 24\%. Out of 92 published cases of TE in children with IBD, 54.3\% occurred in cerebral site, 26\% in the limbs, 13\% in the abdominal vessels, and the remaining in the retina and lungs. After a first episode of TE, an early recurrence was observed in 11.4\% of children, a late recurrence in 10\%. A number of different therapeutic schemes were used. Overall mortality was 5.7\% and was mostly associated with cerebral TE.

CONCLUSIONS: Population studies are needed to clarify the risk of TE in children with IBD, the relative weight of other risk factors, the characteristics of the events, and to define guidelines of therapy and prophylaxis.

}, keywords = {Adult, Child, Humans, Inflammatory Bowel Diseases, Risk Factors, Thromboembolism}, issn = {1536-4844}, doi = {10.1002/ibd.21563}, author = {Lazzerini, Marzia and Bramuzzo, Matteo and Maschio, Massimo and Martelossi, Stefano and Ventura, Alessandro} } @article {1763, title = {Two lumens, one diagnosis.}, journal = {J Pediatr}, volume = {159}, year = {2011}, month = {2011 Sep}, pages = {511}, keywords = {Capsule Endoscopy, Child, Preschool, Gastrointestinal Hemorrhage, Humans, Male, Meckel Diverticulum, Recurrence}, issn = {1097-6833}, doi = {10.1016/j.jpeds.2011.04.041}, author = {Pastore, Serena and Gortani, Giulia and Maschio, Massimo and Di Leo, Grazia and Ventura, Alessandro} } @article {1675, title = {Splenomegaly as presentation of a wandering spleen.}, journal = {J Pediatr}, volume = {157}, year = {2010}, month = {2010 Nov}, pages = {859.e1}, keywords = {Child, Female, Humans, Splenomegaly, Wandering Spleen}, issn = {1097-6833}, doi = {10.1016/j.jpeds.2010.04.046}, author = {Maschio, Massimo and Cozzi, Giorgio and Sanabor, Daniela and Zennaro, Floriana and Gloria, Pelizzo and Barbi, Egidio} }