@article {10477, title = {Somatic symptom disorder was common in children and adolescents attending an emergency department complaining of pain.}, journal = {Acta Paediatr}, volume = {106}, year = {2017}, month = {2017 Apr}, pages = {586-593}, abstract = {

AIM: The aim of this study was to quantify the prevalence of somatic pain in a paediatric emergency department (ED).

METHODS: We conducted a prospective observational study using patients admitted to the ED of an Italian children{\textquoteright}s hospital between December 2014 and February 2015. We enrolled children aged 7-17 who turned up at the ED complaining of pain. Patients and parents were asked to fill in a questionnaire to allow the analysis of the patients{\textquoteright} medical history and provide contact details for follow-up. We divided the enrolled patients into four groups: post-traumatic pain, organic pain, functional pain and somatic pain. The questionnaire was used to define pain characteristics and to generate an impairment score.

RESULTS: Of the 713 patients who met inclusion criteria, 306 (42.9\%) were enrolled in the study. Of these, 135 (44.0\%) suffered from post-traumatic pain, 104 (34.0\%) from organic pain, 41 (13.4\%) from functional pain and 26 (8.6\%) from somatic pain. Somatic pain patients had endured pain longer, had missed more school days and had suffered severe functional impairment.

CONCLUSION: This study highlighted that somatic pain was a significant contributor to paediatric emergency room visits and should be suspected and diagnosed in children reporting pain.

}, keywords = {Adolescent, Child, Emergency Service, Hospital, Female, Humans, Italy, Male, Medically Unexplained Symptoms, Pain, Prospective Studies}, issn = {1651-2227}, doi = {10.1111/apa.13741}, author = {Cozzi, Giorgio and Minute, Marta and Skabar, Aldo and Pirrone, Angela and Jaber, Mohamad and Neri, Elena and Montico, Marcella and Ventura, Alessandro and Barbi, Egidio} } @article {1966, title = {A red baby should not be taken too lightly.}, journal = {Acta Paediatr}, volume = {101}, year = {2012}, month = {2012 Dec}, pages = {e573-7}, abstract = {

AIM: To identify clinical and laboratory features that can drive the differential diagnosis of a primary immunodeficiency diseases in patients with ectodermal defects.

METHODS: Analysis of selected teaching cases.

RESULTS: We identified four exemplary cases that allowed to point out specific clues.

CONCLUSIONS: A careful evaluation of immune and ectodermal signs is the key to the diagnosis. Therefore, a multidisciplinary approach can lead to diagnosis and to an appropriate treatment in most of the cases.

}, keywords = {Child, Preschool, Dermatitis, Ectodermal Dysplasia, Female, Humans, Immunologic Deficiency Syndromes, Infant, Male, Netherton Syndrome, Severe Combined Immunodeficiency, Skin}, issn = {1651-2227}, doi = {10.1111/apa.12018}, author = {Faletra, Flavio and Bruno, Irene and Berti, Irene and Pastore, Serena and Pirrone, Angela and Tommasini, Alberto} } @article {1711, title = {The universe of immune deficiencies in Crohn{\textquoteright}s disease: a new viewpoint for an old disease?}, journal = {Scand J Gastroenterol}, volume = {45}, year = {2010}, month = {2010 Oct}, pages = {1141-9}, abstract = {

Crohn{\textquoteright}s disease (CD) is generally considered a multifactorial disorder, since different genetic and environmental factors are thought to play a role in its pathogenesis. Recently, genome wide linkage studies allowed to identify the association of several loci with the increased risk of CD, although it is still unclear how they interact with environmental factors in causing the disease. The fact that many CD-risk-related genes are involved in the function of phagocytes seems in agreement with the well known role of these cells in CD histopathology. Functional defects in cytokine production or in clearance of bacteria in CD patients have recently been reported. Growing evidence that CD could arise from primary phagocyte immunodeficiency is also coming from the study of cases with early onset in infancy. We review such evidences starting from selected cases and discuss the clinical implications of these findings.

}, keywords = {Biological Markers, Crohn Disease, Cytokines, Evidence-Based Medicine, Granulomatous Disease, Chronic, Hematopoietic Stem Cell Transplantation, Humans, Immunosuppressive Agents, Phagocytes, Treatment Outcome, Wiskott-Aldrich Syndrome}, issn = {1502-7708}, doi = {10.3109/00365521.2010.492529}, author = {Tommasini, Alberto and Pirrone, Angela and Palla, Gabriella and Taddio, Andrea and Martelossi, Stefano and Crovella, Sergio and Ventura, Alessandro} }