@article {10474,
	title = {Cubosomes for in vivo fluorescence lifetime imaging.},
	journal = {Nanotechnology},
	volume = {28},
	year = {2017},
	month = {2017 Feb 03},
	pages = {055102},
	abstract = {<p>Herein we provided the first proof of principle for in vivo fluorescence optical imaging application using monoolein-based cubosomes in a healthy mouse animal model. This formulation, administered at a non-cytotoxic concentration, was capable of providing both exogenous contrast for NIR fluorescence imaging with very high efficiency and chemospecific information upon lifetime analysis. Time-resolved measurements of fluorescence after the intravenous injection of cubosomes revealed that the dye rapidly accumulated mainly in the liver, while lifetimes profiles obtained in vivo allowed for discriminating between free dye or dye embedded within the cubosome nanostructure after injection.</p>},
	keywords = {Animals, Carbocyanines, Cell Survival, Drug Compounding, Erythrocytes, Female, Fluorescent Dyes, Glycerides, Humans, Injections, Intravenous, Liposomes, Liver, Mice, Mice, Inbred BALB C, Nanoparticles, NIH 3T3 Cells, Optical Imaging, Particle Size, Spectroscopy, Near-Infrared, Time-Lapse Imaging},
	issn = {1361-6528},
	doi = {10.1088/1361-6528/28/5/055102},
	author = {Biffi, Stefania and Andolfi, Laura and Caltagirone, Claudia and Garrovo, Chiara and Falchi, Angela M and Lippolis, Vito and Lorenzon, Andrea and Macor, Paolo and Meli, Valeria and Monduzzi, Maura and Obiols-Rabasa, Marc and Petrizza, Luca and Prodi, Luca and Rosa, Antonella and Schmidt, Judith and Talmon, Yeshayahu and Murgia, Sergio}
}
