@article {8517,
	title = {Plant Elite Squad: First Defense Line and Resistance Genes - Identification, Diversity and Functional Roles.},
	journal = {Curr Protein Pept Sci},
	year = {2016},
	month = {2016 Jul 24},
	abstract = {<p>Plants exhibit sensitive mechanisms to respond to environmental stresses, presenting some specific and non-specific reactions when attacked by pathogens, including organisms from different classes and complexity, as viroids, viruses, bacteria, fungi and nematodes. A crucial step to define the fate of the plant facing an invading pathogen is the activation of a compatible Resistance (R) gene, the focus of the present review. Different aspects regarding R-genes and their products are discussed, including pathogen recognition mechanisms, signaling and effects on induced and constitutive defense processes, splicing and post transcriptional mechanisms involved. There are still countless challenges to the complete understanding of the mechanisms involving R-genes in plants, in particular those related to the interactions with other genes of the pathogen and of the host itself, their regulation, acting mechanisms at transcriptional and post-transcriptional levels, as well as the influence of other types of stress over their regulation. A magnification of knowledge is expected when considering the novel information from the omics and systems biology.</p>},
	issn = {1875-5550},
	author = {Wanderley-Nogueira, Ana Carolina and Bezerra-Neto, Jo{\~a}o Pac{\'\i}fico and Kido, {\'E}derson Akio and de Ara{\'u}jo, Fl{\'a}via Tadeu and Amorim, Lidiane Lindinalva Barbosa and Crovella, Sergio and Benko-Iseppon, Ana Maria}
}
@article {8520,
	title = {Resistance (R) Genes: Applications and Prospects for Plant Biotechnology and Breeding.},
	journal = {Curr Protein Pept Sci},
	year = {2016},
	month = {2016 Jul 24},
	abstract = {<p>The discovery of novel plant resistance (R) genes (including their homologs and analogs) opened interesting possibilities for controlling plant diseases caused by several pathogens. However, due to environmental pressure and high selection operated by pathogens, several crop plants have lost specificity, broad-spectrum or durability of resistance. On the other hand, the advances in plant genome sequencing and biotechnological approaches, combined with the increasing knowledge on R-genes have provided new insights on their applications for plant genetic breeding, allowing the identification and implementation of novel and efficient strategies that enhance or optimize their use for efficiently controlling plant diseases. The present review focuses on main perspectives of application of R-genes and its co-players for the acquisition of resistance to pathogens in cultivated plants, with emphasis on biotechnological inferences, including transgenesis, cisgenesis, directed mutagenesis and gene editing, with examples of success and challenges to be faced.</p>},
	issn = {1875-5550},
	author = {Pandolfi, Valesca and Neto, Jos{\'e} Ribamar Costa Ferreira and Silva, Manass{\'e}s Daniel and Amorim, Lidiane Lindinalva Barbosa and Wanderley-Nogueira, Ana Carolina and de Oliveira Silva, Roberta Lane and Kido, {\'E}derson Akio and Crovella, Sergio and Iseppon, Ana Maria Benko}
}
