@article {1963,
	title = {Polymorphisms in DC-SIGN and L-SIGN genes are associated with HIV-1 vertical transmission in a Northeastern Brazilian population.},
	journal = {Hum Immunol},
	volume = {73},
	year = {2012},
	month = {2012 Nov},
	pages = {1159-65},
	abstract = {<p>DC-SIGN and L-SIGN are receptors expressed on specialized macrophages in decidua, (Hofbauer and placental capillary endothelial cells), known to interact with several pathogens, including HIV-1. To disclose the possible involvement of these molecules in the susceptibility to HIV vertical transmission, we analyzed DC-SIGN and L-SIGN gene single nucleotide polymorphisms (SNPs) in 192 HIV-1 positive children and 58 HIV-1 negative children all born to HIV-1 positive mothers, as well as 96 healthy uninfected children not exposed to HIV-1, all from Northeast Brazil. The frequency of three SNPs in the DC-SIGN promoter (-139G>A, -201G>T and -336A>G) were significantly different when comparing HIV positive children with HIV-1 exposed uninfected children, indicating an association with susceptibility to HIV-1 vertical transmission. This genetic association suggests that DC-SIGN molecule may play a role in susceptibility to HIV-1 infection through vertical transmission.</p>},
	keywords = {Alleles, Brazil, Cell Adhesion Molecules, Child, Child, Preschool, Exons, Female, Gene Frequency, Genotype, HIV Infections, HIV-1, Humans, Infectious Disease Transmission, Vertical, Lectins, C-Type, Male, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Receptors, Cell Surface, Tandem Repeat Sequences},
	issn = {1879-1166},
	doi = {10.1016/j.humimm.2012.07.338},
	author = {da Silva, Ronaldo Celerino and Segat, Ludovica and Zanin, Valentina and Arraes, Luiz Claudio and Crovella, Sergio}
}
