@article {7690,
	title = {Short Communication FYB polymorphisms in Brazilian patients with type I diabetes mellitus and autoimmune polyglandular syndrome type III.},
	journal = {Genet Mol Res},
	volume = {14},
	year = {2015},
	month = {2015},
	pages = {29-33},
	abstract = {<p>The aim of this study was to perform an association study between seven Fyn-binding protein gene (FYB)-tag single nucleotide polymorphisms (SNPs) and type I diabetes mellitus (T1DM), as well as with disease age of onset. We also assessed the role of FYB SNPs in the insurgence of autoimmune polyglandular syndrome type III (APSIII), characterized by the simultaneous presence of autoimmune thyroid disease and celiac disease, in patients with T1DM from a Northeastern Brazilian population. One hundred and seventy-seven patients with T1DM and 190 healthy individuals were genotyped for seven tag SNPs, covering most of the FYB locus, using real-time polymerase chain reaction amplification. There was no significant difference in the distribution of allele and genotype frequencies among patients and healthy individuals. Moreover, none of the tag SNPs were associated either to T1DM age of onset or to the insurgence of APSIII. However, since the FYB protein is a key component in T cell response, its gene variants might play a role in protein function, which might be testable in a population with different genetic backgrounds or by using functional assays.</p>},
	issn = {1676-5680},
	doi = {10.4238/2015.January.15.4},
	author = {Addobbati, C J C and de Azev{\^e}do Silva, J and Tavares, N A C and Araujo, J and Guimar{\~a}es, R L and Brand{\~a}o, L and Crovella, S and Sandrin-Garcia, P}
}
@article {1869,
	title = {Association of MBL2 gene exon 1 variants with autoimmune thyroid disease in Brazilian patients.},
	journal = {Int J Immunogenet},
	volume = {39},
	year = {2012},
	month = {2012 Aug},
	pages = {357-61},
	abstract = {<p>We investigated the association between MBL2 gene exon 1 functional polymorphisms and autoimmune thyroid disease (AITD) in 163 Brazilian patients (87 with Hashimoto thyroiditis, HT; 76 with Graves{\textquoteright} disease) and 214 healthy controls. Individuals carrying MBL2 O allele are at higher risk of developing AITD (OR = 1.58, 95\% CI: 1.11-2.26; P-value = 0.009) and HT (OR = 1.67, 95\% CI: 1.09-2.55; P-value = 0.013) as suggesting a possible role for mannose-binding lectin in influencing disease susceptibility.</p>},
	keywords = {Adolescent, Adult, Brazil, Case-Control Studies, Child, Child, Preschool, Exons, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genetic Testing, Graves Disease, Hashimoto Disease, Humans, Infant, Male, Mannose-Binding Lectin, Middle Aged, Polymorphism, Single Nucleotide, Young Adult},
	issn = {1744-313X},
	doi = {10.1111/j.1744-313X.2012.01102.x},
	author = {Filho, C B and Rodrigues, F F and Segat, L and Fonseca, A M and Araujo, J and Arahata, C and Pontes, L and Vilar, L and de Lima Filho, J L and Crovella, S}
}
