@article {8506, title = {Amniocentesis and chorionic villus sampling in HIV-infected pregnant women: a multicentre case series.}, journal = {BJOG}, volume = {124}, year = {2017}, month = {2017 Jul}, pages = {1218-1223}, abstract = {

OBJECTIVES: To assess in pregnant women with HIV the rates of amniocentesis and chorionic villus sampling (CVS), and the outcomes associated with such procedures.

DESIGN: Observational study. Data from the Italian National Program on Surveillance on Antiretroviral Treatment in Pregnancy were used.

SETTING: University and hospital clinics.

POPULATION: Pregnant women with HIV.

METHODS: Temporal trends were analysed by analysis of variance and by the Chi-square test for trend. Quantitative variables were compared by Student{\textquoteright}s t-test and categorical data by the Chi-square test, with odds ratios and 95\% confidence intervals calculated.

MAIN OUTCOME MEASURES: Rate of invasive testing, intrauterine death, HIV transmission.

RESULTS: Between 2001 and 2015, among 2065 pregnancies in women with HIV, 113 (5.5\%) had invasive tests performed. The procedures were conducted under antiretroviral treatment in 99 cases (87.6\%), with a significant increase over time in the proportion of tests performed under highly active antiretroviral therapy (HAART) (100\% in 2011-2015). Three intrauterine deaths were observed (2.6\%), and 14 pregnancies were terminated because of fetal anomalies. Among 96 live newborns, eight had no information available on HIV status. Among the remaining 88 cases with either amniocentesis (n = 75), CVS (n = 12), or both (n = 1), two HIV transmissions occurred (2.3\%). No HIV transmission occurred among the women who were on HAART at the time of invasive testing, and none after 2005.

CONCLUSIONS: The findings reinforce the assumption that invasive prenatal testing does not increase the risk of HIV vertical transmission among pregnant women under suppressive antiretroviral treatment.

TWEETABLE ABSTRACT: No HIV transmission occurred among women who underwent amniocentesis or CVS under effective anti-HIV regimens.

}, keywords = {Adult, Amniocentesis, Analysis of Variance, Anti-Retroviral Agents, Chi-Square Distribution, Chorionic Villi Sampling, Female, Fetal Death, HIV Infections, Humans, Infectious Disease Transmission, Vertical, Odds Ratio, Pregnancy, Pregnancy Complications, Infectious}, issn = {1471-0528}, doi = {10.1111/1471-0528.14183}, author = {Floridia, M and Masuelli, G and Meloni, A and Cetin, I and Tamburrini, E and Cavaliere, A F and Dalzero, S and Sansone, M and Alberico, S and Guerra, B and Spinillo, A and Chiad{\`o} Fiorio Tin, M and Ravizza, M} } @article {3594, title = {Is "option B+" also being adopted in pregnant women in high-income countries? Temporal trends from a national study in Italy.}, journal = {Clin Infect Dis}, volume = {60}, year = {2015}, month = {2015 Jan 1}, pages = {159-61}, keywords = {Anti-Retroviral Agents, Antiretroviral Therapy, Highly Active, Developed Countries, Female, HIV Infections, Humans, Infant, Newborn, Italy, Patient Acceptance of Health Care, Pregnancy, Pregnancy Complications, Infectious}, issn = {1537-6591}, doi = {10.1093/cid/ciu736}, author = {Floridia, Marco and Guaraldi, Giovanni and Ravizza, Marina and Tibaldi, Cecilia and Pinnetti, Carmela and Maccabruni, Anna and Molinari, Atim and Liuzzi, Giuseppina and Alberico, Salvatore and Meloni, Alessandra and Rizzi, Laura and Dalzero, Serena and Tamburrini, Enrica} } @article {1987, title = {Use of specific antiretroviral regimens among HIV-infected women in Italy at time of conception: 2001-2011.}, journal = {AIDS Patient Care STDS}, volume = {26}, year = {2012}, month = {2012 Aug}, pages = {439-43}, keywords = {Anti-HIV Agents, Drug Administration Schedule, Female, Fertilization, HIV Protease Inhibitors, HIV Seropositivity, Humans, Infectious Disease Transmission, Vertical, Italy, Pregnancy, Reverse Transcriptase Inhibitors, Sentinel Surveillance}, issn = {1557-7449}, doi = {10.1089/apc.2012.0116}, author = {Floridia, Marco and Ravizza, Marina and Guaraldi, Giovanni and Pinnetti, Carmela and Martinelli, Pasquale and Tamburrini, Enrica} } @article {1852, title = {Rubella susceptibility profile in pregnant women with HIV.}, journal = {Clin Infect Dis}, volume = {52}, year = {2011}, month = {2011 Apr 1}, pages = {960-2}, keywords = {Female, HIV Infections, Humans, Pregnancy, Pregnancy Complications, Infectious, Rubella}, issn = {1537-6591}, doi = {10.1093/cid/cir040}, author = {Floridia, Marco and Pinnetti, Carmela and Ravizza, Marina and Tibaldi, Cecilia and Sansone, Matilde and Fiscon, Marta and Guaraldi, Giovanni and Guerra, Brunella and Alberico, Salvatore and Spinillo, Arsenio and Castelli, Paula and Dalzero, Serena and Cavaliere, Anna Franca and Tamburrini, Enrica} } @article {1663, title = {Declining HCV seroprevalence in pregnant women with HIV.}, journal = {Epidemiol Infect}, volume = {138}, year = {2010}, month = {2010 Sep}, pages = {1317-21}, abstract = {

We assessed recent trends in hepatitis C virus (HCV) prevalence in pregnant women with HIV using data from a large national study. Based on 1240 pregnancies, we observed a 3.4-fold decline in HCV seroprevalence in pregnant women with HIV between 2001 (29.3\%) and 2008 (8.6\%). This decline was the net result of two components: a progressively declining HCV seroprevalence in non-African women (from 35.7\% in 2001 to 16.7\% in 2008), sustained by a parallel reduction in history of injecting drug use (IDU) in this population, and a significantly growing presence (from 21.2\% in 2001 to 48.6\% in 2008) of women of African origin, at very low risk of being HCV-infected [average HCV prevalence 1\%, adjusted odds ratio (aOR) for HCV 0.09, 95\% CI 0.03-0.29]. Previous IDU was the stronger determinant of HCV co-infection in pregnant women with HIV (aOR 30.9, 95\% CI 18.8-51.1). The observed trend is expected to translate into a reduced number of cases of vertical HCV transmission.

}, keywords = {Chi-Square Distribution, Female, Hepatitis C, HIV Infections, Humans, Italy, Logistic Models, Pregnancy, Risk Factors, Seroepidemiologic Studies}, issn = {1469-4409}, doi = {10.1017/S0950268810000129}, author = {Floridia, M and Tamburrini, E and Anzidei, G and Tibaldi, C and Muggiasca, M L and Guaraldi, G and Fiscon, M and Vimercati, A and Martinelli, P and Donisi, A and Dalzero, S and Ravizza, M} }