@article {8287,
	title = {MBL2 genetic polymorphisms and HIV-1 mother-to-child transmission in Zambia.},
	journal = {Immunol Res},
	volume = {64},
	year = {2016},
	month = {2016 Jun},
	pages = {775-84},
	abstract = {<p>Since antiretroviral drugs have been introduced to prevent mother-to-child transmission, the risk of HIV-1 infection in infants has decreased considerably worldwide. Nevertheless, many factors are involved in viral transmission and host susceptibility to infection. The immune system and its components, including mannose binding protein C (encoding by MBL2 gene), are already known to play an important role in this scenario. In the present study, 313 children and 98 of their mothers from Zambia were genotyped for the MBL2 promoter HL (rs11003125) and XY (rs7096206) polymorphisms and exon 1 D (rs5030737, at codon 52) B (rs1800450, at codon 54) and C (rs1800451, at codon 57) polymorphisms in order to investigate the potential role of these genetic variants in HIV-1 mother-to-child transmission. No statistical significant association was observed comparing transmitter and non-transmitter mothers and also confronting HIV-positive and HIV-negative children. The findings of the current study obtained on mother and children from Zambia evidence lack of association between MBL2 functional polymorphisms and HIV-1 mother-to-child transmission.</p>},
	issn = {1559-0755},
	doi = {10.1007/s12026-015-8779-1},
	author = {Zupin, Luisa and Polesello, Vania and Segat, Ludovica and Kuhn, Louise and Crovella, Sergio}
}
@article {7758,
	title = {MBL2 polymorphisms in women with atypical squamous cells of undetermined significance.},
	journal = {J Med Virol},
	volume = {87},
	year = {2015},
	month = {2015 May},
	pages = {851-9},
	abstract = {<p>Infection with high risk Human papillomavirus (HPV) is the main known cause of cervical cancer. HPV induces different grades of lesions: among them, Atypical squamous cells of undetermined significance are abnormal lesions that could evolve in pre-cancer lesions or spontaneously regress. The mannose binding lectin (MBL) is an innate immunity serum protein also found in cervico-vaginal mucosa, whose expression is known to be affected by polymorphisms in exon 1 and promoter of the MBL2 gene. In the present study the possible association between MBL2 functional polymorphisms and susceptibility to develop atypical squamous cells of undetermined significance was investigated in a group of women from North-East of Italy, stratified for HPV infection status. The MBL2 D and O alleles and the deficient producer combined genotypes, responsible for low MBL production, were more represented among atypical squamous cells of undetermined significance positive women than healthy controls and the results were confirmed when only HPV negative samples were considered. These results suggest a possible involvement of MBL2 functional polymorphisms in atypical squamous cells of undetermined significance susceptibility.</p>},
	keywords = {Adolescent, Adult, Atypical Squamous Cells of the Cervix, Female, Gene Frequency, Genetic Predisposition to Disease, Humans, Italy, Mannose-Binding Lectin, Polymorphism, Single Nucleotide, Young Adult},
	issn = {1096-9071},
	doi = {10.1002/jmv.24080},
	author = {Zupin, Luisa and Polesello, Vania and Casalicchio, Giorgia and Freato, Nadia and Maestri, Iva and Comar, Manola and Crovella, Sergio and Segat, Ludovica}
}
