@article {10832,
	title = {Photobiomodulation at Multiple Wavelengths Differentially Modulates Oxidative Stress  and .},
	journal = {Oxid Med Cell Longev},
	volume = {2018},
	year = {2018},
	month = {2018},
	pages = {6510159},
	abstract = {<p>Photobiomodulation (PBM) is emerging as an effective strategy for the management of multiple inflammatory conditions, including oral mucositis (OM) in cancer patients who receive chemotherapy or radiotherapy. Still, the poor understanding of the mechanisms by which the light interacts with biological tissues and the heterogeneity of light sources and protocols employed worldwide significantly limits its applicability. Reactive oxygen species (ROS) are massively generated during the early phases of OM and play a major role in the pathogenesis of inflammation in general. Here, we report the results of a clinical and experimental study, aimed at evaluating the effect of laser light at different wavelengths on oxidative stress  in oncologic patients suffering from OM and  in two cell types abundantly present within the inflamed oral mucosa, neutrophil polymorphonuclear (PMN) granulocytes, and keratinocytes. In addition to standard ROS detection methods, we exploited a roGFP2-Orp1 genetically encoded sensor, allowing specific, quantitative, and dynamic imaging of redox events in living cells in response to oxidative stress and PBM. We found that the various wavelengths differentially modulate ROS production. In particular, the 660 nm laser light increases ROS production when applied either before or after an oxidative stimulus. In contrast, the 970 nm laser light exerted a moderate antioxidant activity both in the saliva of OM patients and in both cell types. The most marked reduction in the levels of ROS was detected in cells exposed either to the 800 nm laser light or to the combination of the three wavelengths. Overall, our study demonstrates that PBM exerts different effects on the redox state of both PMNs and keratinocytes depending on the used wavelength and prompts the validation of a multiwavelength protocol in the clinical settings.</p>},
	keywords = {Adult, Aged, Aged, 80 and over, Female, Humans, Keratinocytes, Lasers, Semiconductor, Low-Level Light Therapy, Male, Middle Aged, Neutrophils, Oxidation-Reduction, Oxidative Stress, Stomatitis},
	issn = {1942-0994},
	doi = {10.1155/2018/6510159},
	author = {Rupel, Katia and Zupin, Luisa and Colliva, Andrea and Kamada, Anselmo and Poropat, Augusto and Ottaviani, Giulia and Gobbo, Margherita and Fanfoni, Lidia and Gratton, Rossella and Santoro, Massimo and Di Lenarda, Roberto and Biasotto, Matteo and Zacchigna, Serena}
}
@article {8306,
	title = {Protective Role of BST2 Polymorphisms in Mother-to-Child Transmission of HIV-1 and Adult AIDS Progression.},
	journal = {J Acquir Immune Defic Syndr},
	volume = {72},
	year = {2016},
	month = {2016 Jul 1},
	pages = {237-41},
	abstract = {<p>Bone marrow stromal cell antigen-2 (BST-2)/Tetherin is a restriction factor that prevents Human immunodeficiency virus type 1 (HIV-1) release from infected cells and mediates pro-inflammatory cytokine production. This study investigated the risk conferred by single nucleotide polymorphisms (rs919266, rs9192677, and rs9576) at BST-2 coding gene (BST2) in HIV-1 mother-to-child transmission and in disease progression. Initially, 101 HIV-1+ pregnant women and 331 neonates exposed to HIV-1 from Zambia were enrolled. Additional BST2 single nucleotide polymorphism analyses were performed in 2 cohorts with acquired immunodeficiency syndrome (AIDS) progression: an adult Brazilian cohort (37 rapid, 30 chronic and 21 long-term non-progressors) and an Italian pediatric cohort (21 rapid and 67 slow progressors). The rs9576A allele was nominally associated with protection during breastfeeding (P = 0.019) and individuals carrying rs919266 GA showed slower progression to AIDS (P = 0.033). Despite the influence of rs919266 and rs9576 on BST2 expression being still undetermined, a preventive role by BST2 polymorphisms was found during HIV-1 infection.</p>},
	issn = {1944-7884},
	doi = {10.1097/QAI.0000000000000949},
	author = {Kamada, Anselmo J and Bianco, Anna M and Zupin, Luisa and Girardelli, Martina and Matte, Maria C C and Medeiros, R{\'u}bia Mar{\'\i}lia de and Almeida, Sabrina Esteves de Matos and Rocha, Marineide M and Segat, Ludovica and Chies, Jos{\'e} A B and Kuhn, Louise and Crovella, Sergio}
}
