@article {8320,
	title = {DEFB1 gene polymorphisms and tuberculosis in a Northeastern Brazilian population.},
	journal = {Braz J Microbiol},
	volume = {47},
	year = {2016},
	month = {2016 Apr-Jun},
	pages = {389-93},
	abstract = {<p>β-Defensin-1, an antimicrobial peptide encoded by the DEFB1 gene, is known to play an important role in lung mucosal immunity. In our association study we analyzed three DEFB1 functional polymorphisms -52G>A (rs1799946), -44C>G (rs1800972) and -20G>A (rs11362) in 92 tuberculosis patients and 286 healthy controls, both from Northeast Brazil: no association was found between the studied DEFB1 polymorphisms and the disease. However we cannot exclude that this lack of association could be due to the low number of subjects analyzed, as suggested by the low statistical power achieved for the three analyzed SNPs (values between 0.16 and 0.50).</p>},
	issn = {1678-4405},
	doi = {10.1016/j.bjm.2015.09.001},
	author = {Celerino da Silva, Ronaldo and da Cruz, Heidi Lacerda Alves and Brand{\~a}o, Lucas Andr{\'e} Cavalcanti and Guimar{\~a}es, Rafael Lima and Montenegro, Lilian Maria Lapa and Schindler, Haiana Charifker and Segat, Ludovica and Crovella, Sergio}
}
@article {3530,
	title = {Association of CD209 and CD209L polymorphisms with tuberculosis infection in a Northeastern Brazilian population.},
	journal = {Mol Biol Rep},
	volume = {41},
	year = {2014},
	month = {2014 Aug},
	pages = {5449-57},
	abstract = {<p>Tuberculosis (TB) caused by Mycobacterium tuberculosis, is major cause of morbidity and mortality worldwide. So far, many candidate genes have been investigated for their possible association with TB. Dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3) grabbing non-integrin (DC-SIGN) and Liver/lymph node-specific intercellular adhesion molecule-grabbing non-integrin (L-SIGN), encoded by CD209 and CD209L genes respectively, are known for binding to M. tuberculosis on human dendritic cells and macrophages. We screened 4 single nucleotide polymorphisms (SNPs) in the promoter region of CD209, namely -939G>A (rs735240), -871A>G (rs735239), -336A>G (rs4804803) and -139G>A (rs2287886) and tandem repeat polymorphisms in exon 4 of CD209 and CD209L genes looking for association with TB in a Northeastern Brazilian population (295 subjects, 131~TB patients and 164 healthy controls). The -139G>A and -939G>A SNPs were associated with susceptibility to TB, and in particular with pulmonary and extra-pulmonary forms respectively. The -871A>G and -336A>G SNPs were associated, the first with protection to both pulmonary and extra-pulmonary TB, the latter only with the pulmonary form. An association between GGAG haplotype and protection to TB infection was also found. Also tandem repeat polymorphism in CD209L exon 4 was associated with TB infection. This study provides evidence of an association between CD209 and CD209L polymorphisms and TB development in a Brazilian population, suggesting that variations in these genes may influence the protection and susceptibility to infection caused by M. tuberculosis.</p>},
	keywords = {Adult, Alleles, Brazil, Case-Control Studies, Cell Adhesion Molecules, Dendritic Cells, Female, Genetic Predisposition to Disease, Haplotypes, Humans, Lectins, C-Type, Male, Mycobacterium tuberculosis, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Receptors, Cell Surface, Tuberculosis, Young Adult},
	issn = {1573-4978},
	doi = {10.1007/s11033-014-3416-y},
	author = {da Silva, Ronaldo Celerino and Segat, Ludovica and da Cruz, Heidi Lacerda Alves and Schindler, Haiana Charifker and Montenegro, Lilian Maria Lapa and Crovella, Sergio and Guimar{\~a}es, Rafael Lima}
}
