@article {10446,
	title = {Non-invasive biomarkers of fetal brain development reflecting prenatal stress: An integrative multi-scale multi-species perspective on data collection and analysis.},
	journal = {Neurosci Biobehav Rev},
	year = {2018},
	month = {2018 May 30},
	abstract = {<p>Prenatal stress (PS) impacts early postnatal behavioural and cognitive development. This process of {\textquoteright}fetal programming{\textquoteright} is mediated by the effects of the prenatal experience on the developing hypothalamic-pituitary-adrenal (HPA) axis and autonomic nervous system (ANS). We derive a multi-scale multi-species approach to devising preclinical and clinical studies to identify early non-invasively available pre- and postnatal biomarkers of PS. The multiple scales include brain epigenome, metabolome, microbiome and the ANS activity gauged via an array of advanced non-invasively obtainable properties of fetal heart rate fluctuations. The proposed framework has the potential to reveal mechanistic links between maternal stress during pregnancy and changes across these physiological scales. Such biomarkers may hence be useful as early and non-invasive predictors of neurodevelopmental trajectories influenced by the PS as well as follow-up indicators of success of therapeutic interventions to correct such altered neurodevelopmental trajectories. PS studies must be conducted on multiple scales derived from concerted observations in multiple animal models and human cohorts performed in an interactive and iterative manner and deploying machine learning for data synthesis, identification and validation of the best non-invasive detection and follow-up biomarkers, a prerequisite for designing effective therapeutic interventions.</p>},
	issn = {1873-7528},
	doi = {10.1016/j.neubiorev.2018.05.026},
	author = {Frasch, Martin G and Lobmaier, Silvia M and Stampalija, Tamara and Desplats, Paula and Pallar{\'e}s, Mar{\'\i}a Eugenia and Pastor, Ver{\'o}nica and Brocco, Marcela A and Wu, Hau-Tieng and Schulkin, Jay and Herry, Christophe L and Seely, Andrew J E and Metz, Gerlinde A S and Louzoun, Yoram and Antonelli, Marta C}
}
@article {8081,
	title = {New lenses to look at preeclampsia.},
	journal = {Gynecol Endocrinol},
	year = {2015},
	month = {2015 Nov 25},
	pages = {1-4},
	issn = {1473-0766},
	doi = {10.3109/09513590.2015.1115833},
	author = {Zullino, Sara and Di Martino, Daniela and Stampalija, Tamara and Ferrazzi, Enrico}
}
