@article {7705, title = {Does defibrotide induce a delay to polymorphonuclear neutrophil engraftment after hematopoietic stem cell transplantation? Observation in a pediatric population.}, journal = {Adv Ther}, volume = {32}, year = {2015}, month = {2015 Apr}, pages = {381-6}, abstract = {

INTRODUCTION: In recent years, defibrotide (DFT) has emerged as a promising therapy for veno-occlusive disease (VOD). The aim of this study was to investigate whether DFT prophylaxis affects neutrophil engraftment in patients undergoing hematopoietic stem cell transplantation (HSCT).

METHODS: A cohort of 44 consecutive pediatric patients who underwent HSCT was retrospectively analyzed to see the role of DFT on engraftment. Patients were assigned into two groups based on the use or non-use of prophylaxis with DFT.

RESULTS: The mean time to engraftment was statistically different between the two groups for both polymorphonuclear neutrophils (PMN) and white blood cells.

CONCLUSION: Our study supports the hypothesis that prophylaxis with DFT for VOD leads to a delay to the engraftment of PMN in pediatric patients that underwent HSCT.

}, issn = {1865-8652}, doi = {10.1007/s12325-015-0203-7}, author = {Maximova, Natalia and Pizzol, Antonio and Giurici, Nagua and Granzotto, Marilena} } @article {7737, title = {Role of Pharmacogenetics in Hematopoietic Stem Cell Transplantation Outcome in Children.}, journal = {Int J Mol Sci}, volume = {16}, year = {2015}, month = {2015}, pages = {18601-27}, abstract = {

Hematopoietic stem cell transplantation (HSCT) is an established therapeutic procedure for several congenital and acquired disorders, both malignant and nonmalignant. Despite the great improvements in HSCT clinical practices over the last few decades, complications, such as graft vs. host disease (GVHD) and sinusoidal obstructive syndrome (SOS), are still largely unpredictable and remain the major causes of morbidity and mortality. Both donor and patient genetic background might influence the success of bone marrow transplantation and could at least partially explain the inter-individual variability in HSCT outcome. This review summarizes some of the recent studies on candidate gene polymorphisms in HSCT, with particular reference to pediatric cohorts. The interest is especially focused on pharmacogenetic variants affecting myeloablative and immunosuppressive drugs, although genetic traits involved in SOS susceptibility and transplant-related mortality are also reviewed.

}, issn = {1422-0067}, doi = {10.3390/ijms160818601}, author = {Franca, Raffaella and Stocco, Gabriele and Favretto, Diego and Giurici, Nagua and Decorti, Giuliana and Rabusin, Marco} } @article {3501, title = {A boy with sudden headache.}, journal = {Pediatr Emerg Care}, volume = {30}, year = {2014}, month = {2014 Mar}, pages = {182-4}, abstract = {

Headache is a common presenting complaint in pediatric emergency departments. The goal of emergent evaluation is to identify those children with potentially life-threatening conditions. We present the case of an adolescent boy presenting with headache and hypertension who was diagnosed with a catecholamine-secreting abdominal paraganglioma. Genetic testing eventually led to the diagnosis of SDHB-related hereditary paraganglioma-pheochromocytoma syndrome. Alarm features ("red flags") in children presenting with headache are reviewed, as well as the main features of paragangliomas and the indications for genetic testing.

}, keywords = {Abdominal Neoplasms, Adolescent, Emergencies, Headache, Humans, Male, Paraganglioma}, issn = {1535-1815}, doi = {10.1097/PEC.0000000000000090}, author = {Norbedo, Stefania and Naviglio, Samuele and Murru, Flora Maria and Cavallin, Roberta and Giurici, Nagua and Rabusin, Marco and Barbi, Egidio} } @article {1912, title = {Importance of bladder bowel dysfunction in patients with urinary tract infection.}, journal = {J Pediatr}, volume = {161}, year = {2012}, month = {2012 Aug}, pages = {370; author reply 370}, keywords = {Cystoscopy, Female, Fever, Humans, Male, Ureteroscopy, Urinary Tract Infections, Vesico-Ureteral Reflux}, issn = {1097-6833}, doi = {10.1016/j.jpeds.2012.04.014}, author = {Giurici, Nagua and Pennesi, Marco} } @article {1762, title = {Consensus on diagnosis and empiric antibiotic therapy of febrile neutropenia.}, journal = {Pediatr Rep}, volume = {3}, year = {2011}, month = {2011 Feb 24}, pages = {e4}, abstract = {

Controversial issues on the management of empiric therapy and diagnosis of febrile neutropenia (FN) were faced by a Consensus Group of the Italian Association of Pediatric Hematology-Oncology (AIEOP). In this paper we report the suggestions of the consensus process regarding the role of aminoglycosides, glycopeptides and oral antibiotics in empiric therapy of FN, the rules for changing or discontinuing the therapy as well as the timing of the blood cultures.

}, issn = {2036-7503}, doi = {10.4081/pr.2011.e4}, author = {Giurici, Nagua and Zanazzo, Giulio A} } @article {1648, title = {Hot water and preparation of infant formula: how hot does it have to be to be safe?}, journal = {J Pediatr Gastroenterol Nutr}, volume = {50}, year = {2010}, month = {2010 Mar}, pages = {352-3}, keywords = {Guidelines as Topic, Hot Temperature, Humans, Infant, Infant Formula, Water, World Health Organization}, issn = {1536-4801}, doi = {10.1097/MPG.0b013e31819f65b1}, author = {Davanzo, Riccardo and Giurici, Nagua and Demarini, Sergio} }