@article {3603,
	title = {Non-classical MHC-I human leukocyte antigen (HLA-G) in hepatotropic viral infections and in hepatocellular carcinoma.},
	journal = {Hum Immunol},
	volume = {75},
	year = {2014},
	month = {2014 Dec},
	pages = {1225-31},
	abstract = {<p>The human leukocyte antigen (HLA)-G is a "nonclassical" major histocompatibility complex (MHC) class Ib gene, located at chromosome 6, in the 6p21.3 region. The HLA-G presents immunomodulatory functions essential in pregnancy for the tolerance of the semi-allogenic fetus, but an abnormal expression of HLA-G has been observed in numerous pathological conditions, such as tumors, autoimmune diseases and viral infections. In recent years, numerous studies have assessed the clinical relevance of HLA-G expression in different types of cancer: in general, a higher HLA-G expression correlates with a lower survival rate or a shorter disease-free survival. Altered expression of HLA-G has been found in both HCV and HBV infection, and some genetic polymorphisms have been associated with altered susceptibility/disease development for these infections, however, whether the biologic role of HLA-G in HCV and HBV infection is beneficial or hazardous, it is not completely clear. In the context of hepatocellular carcinoma, HLA-G has shown a potential diagnostic role, moreover a prognostic value in HCC patients has been also attributed to HLA-G molecules. We revise here the role of HLA-G in hepatotropic HBV/HCV infections and in hepatocellular carcinoma (HCC).</p>},
	keywords = {Carcinoma, Hepatocellular, Female, Genetic Predisposition to Disease, Hepatitis B, Hepatitis C, HLA-G Antigens, Humans, Immune Tolerance, Liver Neoplasms, Polymorphism, Genetic, Pregnancy},
	issn = {1879-1166},
	doi = {10.1016/j.humimm.2014.09.019},
	author = {Catamo, Eulalia and Zupin, Luisa and Crovella, Sergio and Celsi, Fulvio and Segat, Ludovica}
}
@article {1731,
	title = {NALP1/NLRP1 genetic variants are associated with Alzheimer disease.},
	journal = {Alzheimer Dis Assoc Disord},
	volume = {26},
	year = {2012},
	month = {2012 Jul-Sep},
	pages = {277-81},
	abstract = {<p>Alzheimer disease (AD) is a complex neurodegenerative disease. Genetic and molecular studies have confirmed that in the human brain, amyloid-β fibrils can induce, through the activation of NALP1 inflammosome, inflammatory and apoptotic responses involved in the pathogenesis of AD. Considering that AD pathogenesis is multifactorial, we hypothesized that NALP1/NLRP1 could be a susceptibility gene involved in the devolvement of the disease. The possible association between 9 selected polymorphisms in the NALP1/NLRP1 gene and AD was evaluated by comparing their frequency distribution in an Italian cohort of AD patients (AD, n = 276) and in a group of Italian sex-matched and age-matched healthy controls without dementia (HC, n = 266). Our study, evidences the association of 4 nonsynonymous polymorphisms in the NLRP1 gene (rs2137722, rs34733791, rs11657747, rs11651595) with AD. The major alleles of all 4 single nucleotide polymorphisms and the corresponding homozygote genotypes were more frequent in AD patients than in healthy controls, suggesting an association of these variants in the predisposition versus the development of the disease. These findings seem to support the previously reported role of NALP1 in neuronal damage, and provide evidence of an association between single nucleotide variations in the NLRP1 gene and AD.</p>},
	keywords = {Adaptor Proteins, Signal Transducing, Aged, 80 and over, Alzheimer Disease, Apoptosis Regulatory Proteins, Female, Genetic Predisposition to Disease, Genotype, Humans, Italy, Male, Polymerase Chain Reaction, Polymorphism, Single Nucleotide},
	issn = {1546-4156},
	doi = {10.1097/WAD.0b013e318231a8ac},
	author = {Pontillo, Alessandra and Catamo, Eulalia and Arosio, Beatrice and Mari, Daniela and Crovella, Sergio}
}
