@article {10547,
	title = {An Update on the Pathogenesis and Treatment of Chronic Recurrent Multifocal Osteomyelitis in Children.},
	journal = {Paediatr Drugs},
	volume = {19},
	year = {2017},
	month = {2017 Jun},
	pages = {165-172},
	abstract = {<p>Chronic recurrent multifocal osteomyelitis (CRMO), also known as chronic non-bacterial osteomyelitis (CNO), is a rare inflammatory disorder that primarily affects children. It is characterized by pain, local bone expansion, and radiological findings suggestive of osteomyelitis, usually at multiple sites. CRMO predominantly affects the metaphyses of long bones, but involvement of the clavicle or mandible are suggestive of the diagnosis. CRMO is a diagnosis of exclusion, and its pathogenesis remains unknown. Differential diagnosis includes infection, malignancies, benign bone tumors, metabolic disorders, and other autoinflammatory disorders. Biopsy of the bone lesion is not often required but could be necessary in unclear cases, especially for differentiation from bone neoplasia. Non-steroidal anti-inflammatory drugs (NSAIDs) are the first-line treatment. Alternative therapies have been used, including corticosteroids, methotrexate, bisphosphonates, and tumor necrosis factor (TNF)-α inhibitors. No guidelines have been established regarding diagnosis and treatment options. This manuscript gives an overview of the most recent findings on the pathogenesis of CRMO and clinical approaches for patients with the condition.</p>},
	keywords = {Adrenal Cortex Hormones, Anti-Inflammatory Agents, Non-Steroidal, Child, Chronic Disease, Diagnosis, Differential, Humans, Osteomyelitis, Recurrence, Tumor Necrosis Factor-alpha},
	issn = {1179-2019},
	doi = {10.1007/s40272-017-0226-4},
	author = {Taddio, Andrea and Zennaro, Floriana and Pastore, Serena and Cimaz, Rolando}
}
@article {3582,
	title = {An unusual long-term complication of transobturator polypropylene mesh.},
	journal = {Arch Gynecol Obstet},
	volume = {290},
	year = {2014},
	month = {2014 Dec},
	pages = {1273-4},
	abstract = {<p>Serious complications associated with surgical mesh for transvaginal repair of POP, as infections, vaginal mesh exposure, painful mesh shrinkage and dyspareunia, are not rare. A 48-year-old woman underwent the Perigee procedure because of a stage 3 anterior wall prolapse. Eleven months after surgery, the patient became suddenly unable to walk because of a strong pain to the left thigh root after running. The MRI revealed an external obturator left muscle hyperintensity consistent with muscular oedema; the patient was treated with oral corticosteroids with a complete resolution of the pain. We could hypothesize that the posterior arm of the mesh caused a laceration of the muscles of the obturator space with consequent oedema and pain. The use of the meshes in prolapse surgery can cause unexpected long-term complications.</p>},
	keywords = {Cystocele, Dyspareunia, Female, Glucocorticoids, Humans, Middle Aged, Pelvic Organ Prolapse, Polypropylenes, Postoperative Complications, Prednisone, Surgical Mesh, Treatment Outcome, Vagina},
	issn = {1432-0711},
	doi = {10.1007/s00404-014-3368-4},
	author = {Sartore, Andrea and Zennaro, Floriana and Banco, Rubina}
}
