@article {10438,
	title = {Bariatric surgery drives major rearrangements of the intestinal microbiota including the biofilm composition.},
	journal = {Front Biosci (Elite Ed)},
	volume = {10},
	year = {2018},
	month = {2018 06 01},
	pages = {495-505},
	abstract = {<p>The intestinal microbiota disequilibrium has been associated with obesity, while the role of the gut mucosal biofilms in this pathology is still unknown. We analysed the changes in the intestinal microbiota of obese patients after bariatric surgery with the aim of disclosing the rearrangement of the biofilm configuration. Although the bariatric surgery drives major rearrangements of the gut microbiota, obese patients maintain the  enterotype before and after surgery, as shown by normal weight patients, with an increase of  and . The  enterotype guarantees the strong ability to form a biofilm which allows a more efficient digestion of polysaccharides than planktonic communities and leads to the production of acetate which is a key player to inhibit enteropathogens. Additionally, the laparoscopic gastric bypass induces an increase of , a facultative anaerobic bacterium involved in intestinal and inflammatory disorders. Bariatric surgery influences the microbial composition of gut biofilm. Further studies are needed to elucidate the impact of this variation on recovery after surgery and on weight loss.</p>},
	keywords = {Biofilms, Case-Control Studies, Gastric Bypass, Gastrointestinal Microbiome, Humans, Intestinal Mucosa, Obesity, Prospective Studies},
	issn = {1945-0508},
	author = {Campisciano, Giuseppina and Cason, Carolina and Palmisano, Silvia and Giuricin, Michela and Rizzardi, Alessia and Croce, Lory Saveria and De Manzini, Nicolo and Comar, Manola}
}
@article {3490,
	title = {Beta defensin-1 gene polymorphisms and susceptibility to atypical squamous cells of undetermined significance lesions in Italian gynecological patients.},
	journal = {J Med Virol},
	volume = {86},
	year = {2014},
	month = {2014 Dec},
	pages = {1999-2004},
	abstract = {<p>The role of the human beta-defensin 1 (hBD-1) in the susceptibility to the onset of the Atypical Squamous Cells of Undetermined Significance (ASCUS) lesion, in the presence or not of HPV infection, is still unknown. In the current study, the three functional single nucleotide polymorphisms (SNPs) -52G > A, -44C > G, and -20G > A at the 5{\textquoteright} un-translated region (UTR) of DEFB1 gene, encoding hBD-1, were analyzed in ASCUS lesion gynecological patients and healthy women from the north-east of Italy (Trieste). Cervical samples from 249 European-Caucasian women were collected, screened for HPV and cytologically evaluated; DEFB1 genotyping has been performed by direct sequencing. No significant differences were found for -52G > A, -44C > G, and -20G > A SNPs allele and genotype frequencies between women with and without ASCUS lesions. DEFB1 minor haplotypes were significantly more frequent in ASCUS lesion positive than negative women, associating with an increased risk of this type of lesion. When women were stratified according to HPV infection status, significant differences in the distribution of -52G > A SNP genotype frequencies were found: the presence of the A allele in the homozygous genotype A/A associated with a lower risk of developing ASCUS lesions in HPV negative women. DEFB1 minor haplotypes were also associated with an increased risk of developing ASCUS lesions, being significantly more frequent in HPV negative women with lesions, than without lesions. Although these results highlight the possible involvement of DEFB1, further studies are needed to support the role of DEFB1 in the modulation of the susceptibility to ASCUS lesions.</p>},
	keywords = {5{\textquoteright} Untranslated Regions, Adolescent, Adult, Atypical Squamous Cells of the Cervix, beta-Defensins, Female, Genotype, Humans, Italy, Papillomavirus Infections, Polymorphism, Single Nucleotide, Sequence Analysis, DNA, Uterine Cervical Neoplasms, Young Adult},
	issn = {1096-9071},
	doi = {10.1002/jmv.23878},
	author = {Casalicchio, Giorgia and Freato, Nadia and Maestri, Iva and Comar, Manola and Crovella, Sergio and Segat, Ludovica}
}
