@article {8517,
	title = {Plant Elite Squad: First Defense Line and Resistance Genes - Identification, Diversity and Functional Roles.},
	journal = {Curr Protein Pept Sci},
	year = {2016},
	month = {2016 Jul 24},
	abstract = {<p>Plants exhibit sensitive mechanisms to respond to environmental stresses, presenting some specific and non-specific reactions when attacked by pathogens, including organisms from different classes and complexity, as viroids, viruses, bacteria, fungi and nematodes. A crucial step to define the fate of the plant facing an invading pathogen is the activation of a compatible Resistance (R) gene, the focus of the present review. Different aspects regarding R-genes and their products are discussed, including pathogen recognition mechanisms, signaling and effects on induced and constitutive defense processes, splicing and post transcriptional mechanisms involved. There are still countless challenges to the complete understanding of the mechanisms involving R-genes in plants, in particular those related to the interactions with other genes of the pathogen and of the host itself, their regulation, acting mechanisms at transcriptional and post-transcriptional levels, as well as the influence of other types of stress over their regulation. A magnification of knowledge is expected when considering the novel information from the omics and systems biology.</p>},
	issn = {1875-5550},
	author = {Wanderley-Nogueira, Ana Carolina and Bezerra-Neto, Jo{\~a}o Pac{\'\i}fico and Kido, {\'E}derson Akio and de Ara{\'u}jo, Fl{\'a}via Tadeu and Amorim, Lidiane Lindinalva Barbosa and Crovella, Sergio and Benko-Iseppon, Ana Maria}
}
@article {8518,
	title = {Plants Defense-related Cyclic Peptides: Diversity, Structure and Applications.},
	journal = {Curr Protein Pept Sci},
	year = {2016},
	month = {2016 Jul 24},
	abstract = {<p>Plant growth is prone to several unfavorable factors that may compromise or impair development and survival, including abiotic or biotic stressors. Aiming at defending themselves, plants have developed several strategies to survive and adapt to such adversities. Cyclotides are a family of plant-derived proteins that exhibit a diverse range of biological activities including antimicrobial and insecticidal activities that actively participate in plant defense processes. Three main categories of peptides have been described: (i) Cyclotides (ii) Sunflower Trypsin Inhibitor (SFTI) and (iii) peptides MCoTI-I and II, from Momordica cochinchinensis. They comprise proteins of approximately 30 amino acids, containing a head-to-tail cyclized backbone, with three disulfide bonds configured in a cystine knot topology, therefore bearing greater peptide stability. Given their features and multifunctionality, cyclotides stand out as promising sources for the discovery of new antimicrobial agents. The present review describes cyclotide occurrence, abundance and action in plants, also their diversity and evolution. Considerations regarding their use in the context of biomedical and agronomical sciences uses are also presented.</p>},
	issn = {1875-5550},
	author = {Maria, Ana Carolina Wanderley-Nogueira and Bezerra-Neto, Jo{\~a}o Pac{\'\i}fico and Kido, {\'E}derson Akio and de Ara{\'u}jo, Fl{\'a}via Tadeu and Amorim, Lidiane Lindinalva Barbosa and Crovella, Sergio and Benko-Iseppon, Ana Maria}
}
