@article {1923,
	title = {Simian virus 40 efficiently infects human T lymphocytes and extends their lifespan.},
	journal = {Exp Hematol},
	volume = {40},
	year = {2012},
	month = {2012 Jun},
	pages = {466-76},
	abstract = {<p>The relevance of viral infections to the onset and progression of human hematologic malignancies and other blood diseases is still a matter of active investigation. Purified human T lymphocytes isolated from the peripheral blood mononuclear cells of healthy blood donors were experimentally infected with simian virus 40 (SV40), a small DNA tumor virus. SV40-positive T lymphocytes extended their lifespan up to day 80 postinfection (PI). Expression of viral antigens, such as the large T antigen and the viral capsid protein VP1 from the early and late regions, respectively, was detected up to day 40 PI. SV40 viral progeny were continuously produced from day 10 to 40 PI. SV40 DNA sequences were detected in infected T cells for up to 80 days. Our data indicate that human T lymphocytes can be efficiently infected with SV40. Although T cells infected by SV40 were not immortalized, 30\% of these lymphocytes appeared to be morphologically transformed with an enlarged T-cell shape. Our investigation provides a simple model for studying the interactions of human T lymphocytes with this small DNA tumor virus and it might represent an experimental tool for investigating new biomarkers and targets for innovative therapeutic approaches.</p>},
	keywords = {Antigens, Polyomavirus Transforming, Cell Line, Transformed, Cell Survival, Humans, Microscopy, Electron, Transmission, Simian virus 40, T-Lymphocytes},
	issn = {1873-2399},
	doi = {10.1016/j.exphem.2012.02.008},
	author = {Mazzoni, Elisa and Rigolin, Gian Matteo and Alaribe, Franca Nneka and Pancaldi, Cecilia and Maniero, Stefania and Comar, Manola and Martini, Fernanda and Tognon, Mauro}
}
@article {1721,
	title = {The significance of mannose-binding lectin gene polymorphisms on the risk of BK virus coinfection in women with human papillomavirus-positive cervical lesions.},
	journal = {Hum Immunol},
	volume = {72},
	year = {2011},
	month = {2011 Aug},
	pages = {663-6},
	abstract = {<p>The simultaneous detection of oncogenic human papillomavirus (HPV) and BK virus (BKV) has been recently reported in cervical cancers, suggesting that these viruses may act together in the process of cell transformation; host genetic polymorphisms may also influence virus persistence/reactivation. To disclose a possible role of the gene encoding for the mannose-binding lectin, MBL2, in susceptibility to BKV infection, we analyzed functional polymorphisms in the first exon of MBL2 in women stratified for the presence/absence of BKV and affected by different grades of HPV-induced cervical precancerous lesions. All BKV-positive samples were also HPV positive (HPV 16), and all presented with high-grade squamous intraepithelial lesions. The MBL2 A allele was significantly more frequent in BKV-negative patients than in BKV-positive patients. These data indicate a possible role for the A allele in conferring protection to BKV infection in high-risk HPV-positive women (odds ratio 0.40, 95\% confidence interval 0.20-0.85, p = 0.01).</p>},
	keywords = {Adult, Aged, Alleles, BK Virus, Cervical Intraepithelial Neoplasia, Cervix Uteri, DNA Fingerprinting, DNA, Viral, Female, Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Human papillomavirus 16, Humans, Italy, Mannose-Binding Lectin, Odds Ratio, Papillomavirus Infections, Polymorphism, Genetic, Polyomavirus Infections, Risk, Viral Load},
	issn = {1879-1166},
	doi = {10.1016/j.humimm.2011.04.002},
	author = {Comar, Manola and Segat, Ludovica and Crovella, Sergio and Bovenzi, Massimo and Cortini, Enzo and Tognon, Mauro}
}
