@article {10819,
	title = {MYH9: Structure, functions and role of non-muscle myosin IIA in human disease.},
	journal = {Gene},
	volume = {664},
	year = {2018},
	month = {2018 Jul 20},
	pages = {152-167},
	abstract = {<p>The MYH9 gene encodes the heavy chain of non-muscle myosin IIA, a widely expressed cytoplasmic myosin that participates in a variety of processes requiring the generation of intracellular chemomechanical force and translocation of the actin cytoskeleton. Non-muscle myosin IIA functions are regulated by phosphorylation of its 20 kDa light chain, of the heavy chain, and by interactions with other proteins. Variants of MYH9 cause an autosomal-dominant disorder, termed MYH9-related disease, and may be involved in other conditions, such as chronic kidney disease, non-syndromic deafness, and cancer. This review discusses the structure of the MYH9 gene and its protein, as well as the regulation and physiologic functions of non-muscle myosin IIA with particular reference to embryonic development. Moreover, the review focuses on current knowledge about the role of MYH9 variants in human disease.</p>},
	keywords = {Animals, Cell Line, Deafness, Hearing Loss, Sensorineural, Humans, Mice, Molecular Motor Proteins, Mutation, Myosin Heavy Chains, Neoplasms, Nonmuscle Myosin Type IIA, Phosphorylation, Renal Insufficiency, Chronic, Thrombocytopenia},
	issn = {1879-0038},
	doi = {10.1016/j.gene.2018.04.048},
	author = {Pecci, Alessandro and Ma, Xuefei and Savoia, Anna and Adelstein, Robert S}
}
