TY - JOUR T1 - Fasting increases tobramycin oral absorption in mice. JF - Antimicrob Agents Chemother Y1 - 2010 A1 - De Leo, Luigina A1 - Di Toro, Nicola A1 - Decorti, Giuliana A1 - Malusà, Noelia A1 - Ventura, Alessandro A1 - Not, Tarcisio KW - Administration, Oral KW - Animals KW - Anti-Bacterial Agents KW - Biological Availability KW - Fasting KW - Injections, Intramuscular KW - Injections, Intravenous KW - Intestinal Absorption KW - Lactulose KW - Male KW - Mice KW - Mice, Inbred BALB C KW - Rhamnose KW - Tobramycin AB -

The pharmacokinetics of the aminoglycoside tobramycin was evaluated after oral administration to fed or fasting (15 h) mice. As expected, under normal feeding conditions, oral absorption was negligible; however, fasting induced a dramatic increase in tobramycin bioavailability. The dual-sugar test with lactulose and l-rhamnose confirmed increased small bowel permeability via the paracellular route in fasting animals. When experiments aimed at increasing the oral bioavailability of hydrophilic compounds are performed, timing of fasting should be extremely accurate.

VL - 54 IS - 4 U1 - http://www.ncbi.nlm.nih.gov/pubmed/20086144?dopt=Abstract ER -