TY - JOUR T1 - Declining HCV seroprevalence in pregnant women with HIV. JF - Epidemiol Infect Y1 - 2010 A1 - Floridia, M A1 - Tamburrini, E A1 - Anzidei, G A1 - Tibaldi, C A1 - Muggiasca, M L A1 - Guaraldi, G A1 - Fiscon, M A1 - Vimercati, A A1 - Martinelli, P A1 - Donisi, A A1 - Dalzero, S A1 - Ravizza, M KW - Chi-Square Distribution KW - Female KW - Hepatitis C KW - HIV Infections KW - Humans KW - Italy KW - Logistic Models KW - Pregnancy KW - Risk Factors KW - Seroepidemiologic Studies AB -

We assessed recent trends in hepatitis C virus (HCV) prevalence in pregnant women with HIV using data from a large national study. Based on 1240 pregnancies, we observed a 3.4-fold decline in HCV seroprevalence in pregnant women with HIV between 2001 (29.3%) and 2008 (8.6%). This decline was the net result of two components: a progressively declining HCV seroprevalence in non-African women (from 35.7% in 2001 to 16.7% in 2008), sustained by a parallel reduction in history of injecting drug use (IDU) in this population, and a significantly growing presence (from 21.2% in 2001 to 48.6% in 2008) of women of African origin, at very low risk of being HCV-infected [average HCV prevalence 1%, adjusted odds ratio (aOR) for HCV 0.09, 95% CI 0.03-0.29]. Previous IDU was the stronger determinant of HCV co-infection in pregnant women with HIV (aOR 30.9, 95% CI 18.8-51.1). The observed trend is expected to translate into a reduced number of cases of vertical HCV transmission.

VL - 138 IS - 9 U1 - http://www.ncbi.nlm.nih.gov/pubmed/20096149?dopt=Abstract ER -