TY - JOUR T1 - Association of MBL2 gene exon 1 variants with autoimmune thyroid disease in Brazilian patients. JF - Int J Immunogenet Y1 - 2012 A1 - Filho, C B A1 - Rodrigues, F F A1 - Segat, L A1 - Fonseca, A M A1 - Araujo, J A1 - Arahata, C A1 - Pontes, L A1 - Vilar, L A1 - de Lima Filho, J L A1 - Crovella, S KW - Adolescent KW - Adult KW - Brazil KW - Case-Control Studies KW - Child KW - Child, Preschool KW - Exons KW - Female KW - Genetic Association Studies KW - Genetic Predisposition to Disease KW - Genetic Testing KW - Graves Disease KW - Hashimoto Disease KW - Humans KW - Infant KW - Male KW - Mannose-Binding Lectin KW - Middle Aged KW - Polymorphism, Single Nucleotide KW - Young Adult AB -

We investigated the association between MBL2 gene exon 1 functional polymorphisms and autoimmune thyroid disease (AITD) in 163 Brazilian patients (87 with Hashimoto thyroiditis, HT; 76 with Graves' disease) and 214 healthy controls. Individuals carrying MBL2 O allele are at higher risk of developing AITD (OR = 1.58, 95% CI: 1.11-2.26; P-value = 0.009) and HT (OR = 1.67, 95% CI: 1.09-2.55; P-value = 0.013) as suggesting a possible role for mannose-binding lectin in influencing disease susceptibility.

VL - 39 IS - 4 U1 - http://www.ncbi.nlm.nih.gov/pubmed/22360648?dopt=Abstract ER -