TY - JOUR T1 - Polimorphisms in inflammasome genes are involved in the predisposition to systemic lupus erythematosus. JF - Autoimmunity Y1 - 2012 A1 - Pontillo, Alessandra A1 - Girardelli, Martina A1 - Kamada, Anselmo J A1 - Pancotto, Joao A T A1 - Donadi, Eduardo A A1 - Crovella, Sergio A1 - Sandrin-Garcia, Paula KW - Adaptor Proteins, Signal Transducing KW - Adult KW - Alleles KW - Apoptosis Regulatory Proteins KW - Brazil KW - Female KW - Genetic Predisposition to Disease KW - Genotype KW - Haplotypes KW - Humans KW - Inflammasomes KW - Lupus Erythematosus, Systemic KW - Male KW - Middle Aged KW - Polymorphism, Single Nucleotide AB -

Recent findings provide evidence of inflammasome critical role in the predisposition to autoimmune disorders. The involvement of inflammasome in the pathogenesis of systemic lupus erythematosus (SLE) has been hypothesized even if no significant association within inflammasome genes mutations or polymorphisms and lupus has been reported yet. We analyzed 14 single nucleotide polymorphisms (SNPs) within 7 inflammasome genes (NLRP1, NLRP3, NLRC4, AIM2, CARD8, CASP1, IL1B) in 144 patients affected by systemic lupus erythematosus and in 158 healthy controls from Southern Brazilian (state of São Paulo) with the aim of disclosing the possible role of inflammasome genes in the susceptibility of SLE. Our results demonstrated that NLRP1 rs2670660 SNP and the NLRP1 rs12150220-rs2670660 A-G haplotype were associated with SLE in our study population, and in particular with the development of nephritis, rash and arthritis. These findings are concordant with previously reported association of NLRP1 with vitiligo and type-1 diabetes underlining once more the involvement of NALP1 inflammasome in the pathogenesis of autoimmune disorders.

VL - 45 IS - 4 U1 - http://www.ncbi.nlm.nih.gov/pubmed/22235789?dopt=Abstract ER -