TY - JOUR T1 - Specific protein profile in cerebrospinal fluid from HIV-1-positive cART-treated patients affected by neurological disorders. JF - J Neurovirol Y1 - 2012 A1 - Zanin, Valentina A1 - Delbue, Serena A1 - Marcuzzi, Annalisa A1 - Tavazzi, Eleonora A1 - Del Savio, Rossella A1 - Crovella, Sergio A1 - Marchioni, Enrico A1 - Ferrante, Pasquale A1 - Comar, Manola KW - Adult KW - Aged KW - Anti-HIV Agents KW - Cytokines KW - Encephalomyelitis, Acute Disseminated KW - Female KW - HIV Infections KW - HIV-1 KW - Humans KW - Leukoencephalopathy, Progressive Multifocal KW - Male KW - Middle Aged KW - Pilot Projects AB -

Cytokines/chemokines are involved in the immune response of infections, including HIV-1. We defined the profile of 48 cytokines/chemokines in cerebrospinal fluid from 18 cART patients with chronic HIV-1 infection by Luminex technology. Nine patients were affected with leukoencephalopathies: five with John Cunningham virus (JCV) + progressive multifocal leukoencephalopathy (PML) and four with JCV-not determined leukoencephalopathy (NDLE). In addition, nine HIV-1-positive patients with no neurological signs (NND) and five HIV-1-negative patients affected with acute disseminated encephalomyelitis (ADEM) were enrolled. Ten cytokines (IL-15, IL-3, IL-16, IL-18, CTACK, GRO1, SCF, MCP-1, MIF, SDF) were highly expressed in HIV-1-positive patients while IL-1Ra and IL-17 were present at a lower level. In addition, the levels of IL-17, IL-9, FGF-basic, MIP-1β, and MCP-1 were significantly higher (p < 0.05) in patients with neurological diseases (PML, NDLE, ADEM) with respect to NND. Focusing the attention to the cytokine profile in JCV + PML patients with respect to JCV-NDLE patients, only TNF-β was significantly downregulated (p < 0.05) in JCV + PML patients. This pilot study emphasized the role of immunoregulation in HIV-1-related neurological disorders during cART treatment.

VL - 18 IS - 5 U1 - http://www.ncbi.nlm.nih.gov/pubmed/22581428?dopt=Abstract ER -