TY - JOUR T1 - Gluten-dependent intestinal autoimmune response. JF - Curr Pharm Des Y1 - 2012 A1 - Korponay-Szabó, Ilma Rita A1 - Simon-Vecsei, Zsafia A1 - De Leo, Luigina A1 - Not, Tarcisio KW - Animals KW - Autoantibodies KW - Celiac Disease KW - Genetic Predisposition to Disease KW - Gliadin KW - Glutens KW - Humans KW - Intestinal Mucosa KW - T-Lymphocytes KW - Transglutaminases AB -

Celiac disease is a multi-systemic autoimmune disease of the small bowel induced by gluten in genetically predisposed subjects. Highly specific and gluten-dependent production of auto-antibodies targeting self-proteins of the transglutaminase family occurs in the intestinal mucosa. These anti-transglutaminase antibodies are found deposited in intestinal and extra-intestinal tissue where they might exert biological effects, together with the intestinal mucosal gliadin-specific T lymphocytes. We conducted a brief review on antitransglutaminase antibodies effects, discussing their roles in the pathogenesis of several clinical manifestations of celiac disease.

VL - 18 IS - 35 U1 - http://www.ncbi.nlm.nih.gov/pubmed/22726113?dopt=Abstract ER -