TY - JOUR T1 - Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. JF - Nat Genet Y1 - 2012 A1 - Okada, Yukinori A1 - Sim, Xueling A1 - Go, Min Jin A1 - Wu, Jer-Yuarn A1 - Gu, Dongfeng A1 - Takeuchi, Fumihiko A1 - Takahashi, Atsushi A1 - Maeda, Shiro A1 - Tsunoda, Tatsuhiko A1 - Chen, Peng A1 - Lim, Su-Chi A1 - Wong, Tien-Yin A1 - Liu, Jianjun A1 - Young, Terri L A1 - Aung, Tin A1 - Seielstad, Mark A1 - Teo, Yik-Ying A1 - Kim, Young Jin A1 - Lee, Jong-Young A1 - Han, Bok-Ghee A1 - Kang, Daehee A1 - Chen, Chien-Hsiun A1 - Tsai, Fuu-Jen A1 - Chang, Li-Ching A1 - Fann, S-J Cathy A1 - Mei, Hao A1 - Rao, Dabeeru C A1 - Hixson, James E A1 - Chen, Shufeng A1 - Katsuya, Tomohiro A1 - Isono, Masato A1 - Ogihara, Toshio A1 - Chambers, John C A1 - Zhang, Weihua A1 - Kooner, Jaspal S A1 - Albrecht, Eva A1 - Yamamoto, Kazuhiko A1 - Kubo, Michiaki A1 - Nakamura, Yusuke A1 - Kamatani, Naoyuki A1 - Kato, Norihiro A1 - He, Jiang A1 - Chen, Yuan-Tsong A1 - Cho, Yoon Shin A1 - Tai, E-Shyong A1 - Tanaka, Toshihiro KW - Asian Continental Ancestry Group KW - Blood Urea Nitrogen KW - Cohort Studies KW - Creatinine KW - Genetic Predisposition to Disease KW - Genome-Wide Association Study KW - Glomerular Filtration Rate KW - Humans KW - Kidney KW - Polymorphism, Single Nucleotide KW - Renal Insufficiency, Chronic KW - Uric Acid AB -

Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.

VL - 44 IS - 8 U1 - http://www.ncbi.nlm.nih.gov/pubmed/22797727?dopt=Abstract ER -