TY - JOUR T1 - Association of CD209 and CD209L polymorphisms with tuberculosis infection in a Northeastern Brazilian population. JF - Mol Biol Rep Y1 - 2014 A1 - da Silva, Ronaldo Celerino A1 - Segat, Ludovica A1 - da Cruz, Heidi Lacerda Alves A1 - Schindler, Haiana Charifker A1 - Montenegro, Lilian Maria Lapa A1 - Crovella, Sergio A1 - Guimarães, Rafael Lima KW - Adult KW - Alleles KW - Brazil KW - Case-Control Studies KW - Cell Adhesion Molecules KW - Dendritic Cells KW - Female KW - Genetic Predisposition to Disease KW - Haplotypes KW - Humans KW - Lectins, C-Type KW - Male KW - Mycobacterium tuberculosis KW - Polymorphism, Single Nucleotide KW - Promoter Regions, Genetic KW - Receptors, Cell Surface KW - Tuberculosis KW - Young Adult AB -

Tuberculosis (TB) caused by Mycobacterium tuberculosis, is major cause of morbidity and mortality worldwide. So far, many candidate genes have been investigated for their possible association with TB. Dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3) grabbing non-integrin (DC-SIGN) and Liver/lymph node-specific intercellular adhesion molecule-grabbing non-integrin (L-SIGN), encoded by CD209 and CD209L genes respectively, are known for binding to M. tuberculosis on human dendritic cells and macrophages. We screened 4 single nucleotide polymorphisms (SNPs) in the promoter region of CD209, namely -939G>A (rs735240), -871A>G (rs735239), -336A>G (rs4804803) and -139G>A (rs2287886) and tandem repeat polymorphisms in exon 4 of CD209 and CD209L genes looking for association with TB in a Northeastern Brazilian population (295 subjects, 131 TB patients and 164 healthy controls). The -139G>A and -939G>A SNPs were associated with susceptibility to TB, and in particular with pulmonary and extra-pulmonary forms respectively. The -871A>G and -336A>G SNPs were associated, the first with protection to both pulmonary and extra-pulmonary TB, the latter only with the pulmonary form. An association between GGAG haplotype and protection to TB infection was also found. Also tandem repeat polymorphism in CD209L exon 4 was associated with TB infection. This study provides evidence of an association between CD209 and CD209L polymorphisms and TB development in a Brazilian population, suggesting that variations in these genes may influence the protection and susceptibility to infection caused by M. tuberculosis.

VL - 41 IS - 8 U1 - http://www.ncbi.nlm.nih.gov/pubmed/24874302?dopt=Abstract ER -