TY - JOUR T1 - HLA-G gene polymorphisms associated with susceptibility to rheumatoid arthritis disease and its severity in Brazilian patients. JF - Tissue Antigens Y1 - 2014 A1 - Catamo, E A1 - Addobbati, C A1 - Segat, L A1 - Sotero Fragoso, T A1 - Domingues Barbosa, A A1 - Tavares Dantas, A A1 - de AtaĆ­de Mariz, H A1 - F da Rocha, L A1 - Branco Pinto Duarte, A L A1 - Monasta, L A1 - Sandrin-Garcia, P A1 - Crovella, S KW - 3' Untranslated Regions KW - 5' Flanking Region KW - Aged KW - Arthritis, Rheumatoid KW - Brazil KW - Disease Progression KW - DNA Mutational Analysis KW - Female KW - Gene Frequency KW - Genetic Association Studies KW - Genetic Predisposition to Disease KW - Genotype KW - Haplotypes KW - HLA-G Antigens KW - Humans KW - Male KW - Middle Aged KW - Polymorphism, Single Nucleotide KW - Risk AB -

We analyzed the possible association between human leukocyte antigen-G (HLA-G) genetic variants, supposed to regulate HLA-G expression, and the susceptibility to develop rheumatoid arthritis (RA) as well as its clinical manifestations. The 5'upstream regulatory region (5'URR) and 3'untranslated region (3'UTR) regions of the HLA-G gene were screened in 127 RA patients and 128 controls: 10 5'URR and 3 3'UTR HLA-G polymorphisms as well as two haplotypes were associated with risk for RA development, while a polymorphism in the 5'URR showed an association with the degree of disease activity. These findings, although the number of cases analyzed is limited and the P-values are modest, indicate a possible association between HLA-G gene polymorphisms and susceptibility to develop RA disease and its severity.

VL - 84 IS - 3 U1 - http://www.ncbi.nlm.nih.gov/pubmed/24957665?dopt=Abstract ER -