TY - JOUR T1 - Cerebral oxygenation with different nasal continuous positive airway pressure levels in preterm infants. JF - Arch Dis Child Fetal Neonatal Ed Y1 - 2015 A1 - Bembich, Stefano A1 - Travan, Laura A1 - Cont, Gabriele A1 - Bua, Jenny A1 - Strajn, Tamara A1 - Demarini, Sergio KW - Cerebrovascular Circulation KW - Continuous Positive Airway Pressure KW - Female KW - Hemoglobins KW - Humans KW - Infant, Newborn KW - Infant, Premature KW - Intensive Care, Neonatal KW - Male KW - Nasal Cavity KW - Oxygen KW - Oxygen Consumption KW - Oxyhemoglobins KW - Spectroscopy, Near-Infrared AB -

OBJECTIVES: This study evaluates the effect of varying nasal continuous positive airway pressure (NCPAP) level on cerebral blood flow (CBF) and oxygenation in preterm infants.

METHODS: Oxy-haemoglobin (HbO2) and total haemoglobin (HbTot), as CBF estimates, and the ratio between HbO2 and HbTot (HbO2/HbTot), as cerebral oxygenation estimate, were assessed by near-infrared spectroscopy in 26 stable preterm newborns at a postmenstrual age between 26 and 33 weeks. Baseline HbO2, HbTot and HbO2/HbTot values were initially collected with NCPAP at 5 cm H2O and then compared with values obtained with NCPAP levels at both 3 and 8 cm H2O.

RESULTS: Compared with 5 cm H2O, cerebral HbO2, HbTot and HbO2/HbTot remained unchanged both after increasing (to 8 cm H2O) and decreasing (to 3 cm H2O) the NCPAP level. This result was observed both in regional areas (24 sites) and in the overall monitored area (frontal and parietal cortex). Compared with 8 cm H2O, peripheral oxygen saturation significantly decreased at 3 cm H2O (p=0.021). Heart rate did not change.

CONCLUSIONS: No differences in CBF and cerebral oxygenation were observed with NCPAP levels in the range 3-8 cm H2O despite a decrease in peripheral oxygenation with 3 cm H2O.

VL - 100 IS - 2 U1 - http://www.ncbi.nlm.nih.gov/pubmed/25336677?dopt=Abstract ER -