TY - JOUR T1 - DEFB1 gene polymorphisms and tuberculosis in a Northeastern Brazilian population. JF - Braz J Microbiol Y1 - 2016 A1 - Celerino da Silva, Ronaldo A1 - da Cruz, Heidi Lacerda Alves A1 - Brandão, Lucas André Cavalcanti A1 - Guimarães, Rafael Lima A1 - Montenegro, Lilian Maria Lapa A1 - Schindler, Haiana Charifker A1 - Segat, Ludovica A1 - Crovella, Sergio AB -

β-Defensin-1, an antimicrobial peptide encoded by the DEFB1 gene, is known to play an important role in lung mucosal immunity. In our association study we analyzed three DEFB1 functional polymorphisms -52G>A (rs1799946), -44C>G (rs1800972) and -20G>A (rs11362) in 92 tuberculosis patients and 286 healthy controls, both from Northeast Brazil: no association was found between the studied DEFB1 polymorphisms and the disease. However we cannot exclude that this lack of association could be due to the low number of subjects analyzed, as suggested by the low statistical power achieved for the three analyzed SNPs (values between 0.16 and 0.50).

VL - 47 IS - 2 U1 - http://www.ncbi.nlm.nih.gov/pubmed/26991287?dopt=Abstract ER -