TY - JOUR T1 - Complete remission of VZV reactivation treated with valganciclovir in a patient with total lymphocyte depletion and acute kidney injury after allogeneic bone marrow transplantation. JF - APMIS Y1 - 2015 A1 - Maximova, Natalia A1 - Antonio, Pizzol A1 - Marilena, Granzotto A1 - Rovere, Francesca A1 - Tamaro, Paolo KW - Acute Kidney Injury KW - Adolescent KW - Bone Marrow Transplantation KW - Fatal Outcome KW - Female KW - Ganciclovir KW - Herpes Zoster KW - Herpesvirus 3, Human KW - Humans KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma KW - Viral Load AB -

Varicella zoster virus (VZV), a threat for hematopoietic stem cell transplantation (HSCT) recipients, is still one of the most common viral pathogens that affect these patients with a reported incidence ranging between 17% and 50% in the post transplantation period. Valganciclovir (V-GCV), a valine ester pro-drug of GCV orally administrable, has recently shown great activity against CMV infections, but there are no reports of its clinical efficacy against VZV. We here report a case history of a patient with positive serologic test for VZV, who underwent allogeneic HSCT and developed an atypical varicella-like illness. First-line therapy with foscarnet had to be discontinued due rapid development of renal impairment (creatinine: 2.60 mg/dL, urea: 130.6 mg/dL) and therefore was switched to V-GCV. The renal impairment and skin lesions of the patient fully recovered after few days of therapy, even though the patient had complete lymphocyte depletion. This is the first case of a patient with chickenpox-like illness treated successfully with V-GCV.

VL - 123 IS - 1 U1 - http://www.ncbi.nlm.nih.gov/pubmed/25131855?dopt=Abstract ER - TY - JOUR T1 - A web-based system for total parenteral nutrition prescription in a pediatric hospital - biomed 2010. JF - Biomed Sci Instrum Y1 - 2010 A1 - Bava, Michele A1 - Bradashia, Fulvio A1 - Rovere, Francesca A1 - Maestro, Alessandra A1 - Vecchi Brumatti, Liz A1 - Accardo, Agostino A1 - Paparazzo, Rossella A1 - Zanon, Davide AB -

otal Parenteral Nutrition (TPN) is defined as feeding a patient by infusing nutrients intravenously, bypassing the usual process of eating and digestion. There are two kinds of TPN: short-term TPN may be used when a patient's digestive system is temporarily nonfunctional because of an interruption in its continuity; long-term TPN is used to treat patients with an impairment or a lack in nutrient absorption. TPN has extended the life of children born with nonexistent or severely deformed digestive organs and is a vital support for these patients. In Burlos Pediatric Department, pediatricians fill in a pharmacy request form in which nutritional needs are included for each patient. Subsequently, clinical pharmacists evaluate the patients individual data and decide which TPN formula to prepare. To enhance the TPN prescription process, an intranet web-based system has been developed to replicate the original paper-based forms. The software, developed in PHP and based on open source tools and services, has been constructed according to pharmacists requirements. These professionals, together with the Hospital Information System technicians, thanks to the availability of affordable instruments, perceive the advantages that such a system would have in improving clinical practice and quality of care. The system was devised with the goal to avoid common reading errors, to improve the correct text comprehension, to ensure prescription preparation, administration and tracking. According to a process of total quality control, the system reduces clinical risks regarding issues such as the correct and rapid availability of medical prescriptions and the incorrect identification of the patients. In comparison with paper-based TPN prescriptions, electronic-based forms have reduced the incidence of errors, the possible lack of patient data and reading misunderstandings. Regarding future improvements, IT technicians are defining the procedures to implement digital signature and medical aspects of the electronic TPN medical prescriptions.

VL - 46 U1 - http://www.ncbi.nlm.nih.gov/pubmed/20467108?dopt=Abstract ER -