TY - JOUR T1 - Histopathological data of iron and calcium in the mouse lung after asbestos exposure. JF - Data Brief Y1 - 2016 A1 - Trevisan, Elisa A1 - Zabucchi, Giuliano A1 - Pascolo, Lorella A1 - Pascotto, Ernesto A1 - Casarsa, Claudia A1 - Lucattelli, Monica A1 - Lungarella, Giuseppe A1 - Cavarra, Eleonora A1 - Bartalesi, Barbara A1 - Zweyer, Marina A1 - Borelli, Violetta AB -

This data article contains data related to the research article entitled, "Synchrotron X-ray microscopy reveals early calcium and iron interaction with crocidolite fibers in the lung of exposed mice" [1]. Asbestos fibers disrupt iron homeostasis in the human and mouse lung, leading to the deposition of iron (Fe) onto longer asbestos fibers which forms asbestos bodies (AB) [2]. Similar to Fe, calcium (Ca) is also deposited in the coats of the AB. This article presents data on iron and calcium in the mouse lung after asbestos exposure detected by histochemical evaluation.

VL - 6 U1 - http://www.ncbi.nlm.nih.gov/pubmed/26909387?dopt=Abstract ER - TY - JOUR T1 - Synchrotron X-ray microscopy reveals early calcium and iron interaction with crocidolite fibers in the lung of exposed mice. JF - Toxicol Lett Y1 - 2016 A1 - Pascolo, Lorella A1 - Zabucchi, Giuliano A1 - Gianoncelli, Alessandra A1 - Kourousias, George A1 - Trevisan, Elisa A1 - Pascotto, Ernesto A1 - Casarsa, Claudia A1 - Ryan, Chris A1 - Lucattelli, Monica A1 - Lungarella, Giuseppe A1 - Cavarra, Eleonora A1 - Bartalesi, Barbara A1 - Zweyer, Marina A1 - Cammisuli, Francesca A1 - Melato, Mauro A1 - Borelli, Violetta AB -

Human exposure to asbestos can cause a wide variety of lung diseases that are still a current major health concern, even if asbestos has been banned in many countries. It has been shown in many studies that asbestos fibers, ingested by alveolar macrophages, disrupt lung iron homeostasis by sequestering iron. Calcium can also be deposited on the fibers. The pathways along which iron and above all calcium interact with fibers are still unknown. Our aim was that of investigating if the iron accumulation induced by the inhaled asbestos fibers also involves calcium ions accumulation. Lung sections of asbestos-exposed mice were analyzed using an extremely sensitive procedure available at the synchrotron facilities, that provides morphological and chemical information based on X-ray fluorescence microspectroscopy (μ-XRF). In this study we show that (1) where conventional histochemical procedures revealed only weak deposits of iron and calcium, μ-XRF analysis is able to detect significant deposits of both iron and calcium on the inhaled asbestos fibers; (2) the extent of the deposition of these ions is proportionally directly related and (3) iron and calcium deposition on inhaled asbestos fibers is concomitant with the appearance of inflammatory and hyperplastic reactions.

VL - 241 U1 - http://www.ncbi.nlm.nih.gov/pubmed/26602167?dopt=Abstract ER -