TY - JOUR T1 - Cerebrospinal Fluid Cytokine Expression Profile in Multiple Sclerosis and Chronic Inflammatory Demyelinating Polyneuropathy. JF - Immunol Invest Y1 - 2018 A1 - Bonin, Serena A1 - Zanotta, Nunzia A1 - Sartori, Arianna A1 - Bratina, Alessio A1 - Manganotti, Paolo A1 - Trevisan, Giusto A1 - Comar, Manola KW - Adult KW - Aged KW - Biomarkers KW - Central Nervous System KW - Diagnosis, Differential KW - Female KW - Hematopoietic Cell Growth Factors KW - Humans KW - Interleukin-12 KW - Lectins, C-Type KW - Male KW - Middle Aged KW - Multiple Sclerosis KW - Peripheral Nervous System KW - Polyradiculoneuropathy, Chronic Inflammatory Demyelinating KW - Proteins AB -

BACKGROUND: Cerebrospinal fluid (CSF) analysis in patients with particular neurologic disorders is a powerful tool to evaluate specific central nervous system inflammatory markers for diagnostic needs, because CSF represents the specific immune micro-environment to the central nervous system.

METHODS: CSF samples from 49 patients with multiple sclerosis (MS), chronic inflammatory demyelinating polyneuropathy (CIDP), and non-inflammatory neurologic disorders (NIND) as controls were submitted to protein expression profiles of 47 inflammatory biomarkers by multiplex Luminex bead assay to investigate possible differences in the inflammatory process for MS and CIDP.

RESULTS: Our results showed differences in CSF cytokine levels in MS and CIDP; in particular, IL12 (p40) was significantly highly expressed in MS in comparison with CIDP and NIND, while SDF-1α and SCGF-β were significantly highly expressed in CIDP cohort when compared to MS and NIND. IL-9, IL-13, and IL-17 had higher expression levels in NIND if compared with the other groups.

CONCLUSIONS: Our study showed that, despite some common pathogenic mechanisms, central and peripheral nervous system demyelinating diseases, such as MS and CIDP, differ in some specific inflammatory soluble proteins in CSF, underlining differences in the immune response involved in those autoimmune diseases.

VL - 47 IS - 2 U1 - http://www.ncbi.nlm.nih.gov/pubmed/29182448?dopt=Abstract ER -