TY - JOUR T1 - Predictors of Relapse after Discontinuing Systemic Treatment in Childhood Autoimmune Chronic Uveitis. JF - J Rheumatol Y1 - 2017 A1 - Simonini, Gabriele A1 - Bracaglia, Claudia A1 - Cattalini, Marco A1 - Taddio, Andrea A1 - Brambilla, Alice A1 - de Libero, Cinzia A1 - Pires Marafon, Denise A1 - Caputo, Roberto A1 - Cimaz, Rolando KW - Adolescent KW - Antirheumatic Agents KW - Autoimmune Diseases KW - Child KW - Child, Preschool KW - Female KW - Humans KW - Male KW - Predictive Value of Tests KW - Recurrence KW - Retrospective Studies KW - Treatment Outcome KW - Uveitis KW - Withholding Treatment AB -

OBJECTIVE: To identify clinical predictors of relapse in childhood autoimmune chronic uveitis after stopping systemic treatment.

METHODS: A retrospective, multicenter, cohort study.

RESULTS: Ninety-four children in remission, receiving no treatments and with at least a 6-month followup, were enrolled. A higher probability of maintaining remission after discontinuing treatment was shown in idiopathic compared with juvenile idiopathic arthritis uveitis (Mantel-Cox chi-square = 23.21) if inactivity had been obtained within 6 months from starting systemic treatment (Mantel-Cox chi-square = 24.17) and by antitumor necrosis factor-α treatment (Mantel-Cox chi-square = 6.43).

CONCLUSION: Type of disease, time, and type of systemic therapy to achieve inactivity predict different duration of uveitis remission after treatment withdrawal.

VL - 44 IS - 6 U1 - http://www.ncbi.nlm.nih.gov/pubmed/28365583?dopt=Abstract ER -